Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp

Details Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxyp

1986-04-30

1988-03-08

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530323, 530330, 530332, A61K 3743, C07K 706, C07K 702

Patent

active

047299851

ABSTRACT:
A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.

REFERENCES:
patent: 4163676 (1981-09-01), Fuhrer et al.
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4478826 (1984-10-01), Veber et al.
Chem. Abstr., vol. 101:125684m, (1984), for Rich et al., Pept.:Struct. Funct., Proc. Am. Pept. Symp. 8th, 1983, 511-520.
Rich, J. Med. Chem., 28, 263-273, (1985).
Holladay et al., Tetrahedron Letters, 24, 4401-4404, (1983).
Evans et al., J. Org. Chem., 50, 4615-4625, (1985); previously cited as Chem. Abstr. 103:196413z.

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