Renin inhibitors and treatments using them

Details Renin inhibitors and treatments using them Renin inhibitors and treatments using them

1984-08-17

1987-12-15

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530331, C07K 706, C07K 510

Patent

active

047134453

ABSTRACT:
Renin-inhibiting analogues of formula ##STR1## where X and W are terminal groups optionally with further amino acyl residues; D, E, B and Z (of which any one or except with `reduced` analogues any two may be absent) are aromatic, lipophilic or in the case of E aromatic lipophilic or basic amino acid or amino acid analogue residues; and A is an analogue of a lipophilic or aromatic dipeptide residue wherein the peptide link is replaced by a one- to four-atom carbon or carbon-nitrogen link which as such or in hydrated form is an unhydrolysable tetrahedral analogue of the transition state ##STR2## of peptide bond hydrolysis.

REFERENCES:
patent: 4218474 (1980-08-01), Barnish et al.
patent: 4424207 (1984-01-01), Szelke et al.
IUPAC-IUB Commission on Biological Nomenclature, J. Biol. Chem., vol. 247, 977-983, (1972).

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