Renin inhibitors

Details Renin inhibitors Renin inhibitors

1991-10-22

1993-02-23

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, 2609982, 549218, A61K 3700

Patent

active

051890232

ABSTRACT:
Renin inhibiting compounds of the formula: ##STR1## containing two .alpha.-amino acids or a single .alpha.-amino acid wherein R.sub.1 is a phosphorus containing moiety, W is oxygen or NR.sub.3 and A is a moiety selected from those of the formula: ##STR2## wherein Z is O, S, SO, SO.sub.2 and p is an integer from 1 to 2; and, when W is oxygen, A may also be a moiety of the formula ##STR3## and analogs thereof which compounds inhibit the substrate-cleaving action of renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.

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Burger, "Medicinal Chem." 2nd Ed., Interscience, New York 1960, pp. 565-601.
Denkewalter, "Progress in Drug Research", vol. 10, 1966 pp. 510-512.
Bolis, "Renin Inhibitors", J. Med. Chem. 1987, 30: pp. 1729-1737.
Haber, "Renin Inhibitors", J. Cardiovascular Pharm., pp. 554-558 (1987).

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