Renin inhibiting peptides having an .alpha.-heteroatom amino aci

Details Renin inhibiting peptides having an .alpha.-heteroatom amino aci Renin inhibiting peptides having an .alpha.-heteroatom amino aci

1990-01-22

1993-06-22

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530330, 530331, 530800, A61K 3700, C07K 500

Patent

active

052216675

ABSTRACT:
The invention concerns novel renin-inhibitory compounds which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma, and diseases caused by retroviruses including HTLV-I -II, and -III. Processes for preparing the compounds, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

REFERENCES:
patent: 5036054 (1991-07-01), Kaltenbronn
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601.
Plattner et al. J. Med. Chem. 1988, 31(12):2277-2288.
Bolis et al. J. Med. Chem. 1987, 31(10):1729-1737.
Haber et al. J. Cardiovasc. Pharmacol. 1988, 10 (Suppl. 7):S54-S58.

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