Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-05-17
1987-03-24
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, 514616, 530331, 564152, A61K 31165, A61K 3743, C07K 506, C07K 508, C07C10319
Patent
active
046525513
ABSTRACT:
The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is an N-protecting group; n is 0 or 1; B is hydrogen, hydroxy, NH, loweralkyl or arylalkyl; with the proviso that when A is an N-protecting group, B is NH and when n is 0, B is hydrogen, hydroxyl, loweralkyl or arylalkyl; R.sub.1, R.sub.3 and R.sub.5 are loweralkyl or hydrophilic, lipophilic or aromatic amino acid side chains and may be the same or different; R.sub.2, R.sub.4, R.sub.7, R.sub.8 and R.sub.9 are hydrogen or loweralkyl and may be the same or different; X is CH.sub.2 ; R.sub.6 is loweralkyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl; and X and R.sub.6 when taken together may be a vinylic group.
REFERENCES:
patent: 4384994 (1983-05-01), Veber et al.
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Chem. Abstr. vol. 103, p. 54459v 198.
Journal of Medicinal Chemistry 28, No. 3 (1985), 263-273.
Journal of Chem. and Engineering 13, (1968) 450-451.
Kokubu et al., Biochemical and Biophysical Research Communications, 118, No. 3, 929-933 (1984).
Evin et al., Proceedings of the Eighth American Peptide Symposium, 583-586 (1984).
Johnson, J. Med. Chem., 23, 666-669 (1980).
Rodinger, Peptide Hormones, Parsons (ed.), U. Park Press, Baltimore, 1976, pp. 1-7.
Dellaria Joseph F.
Luly Jay R.
Plattner John J.
Abbott Laboratories
Katz Martin L.
Phillips Delbert R.
Weinstock Steven F.
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