Renin inhibiting compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530331, 530330, A61K 3743, C07K 508

Patent

active

046457593

ABSTRACT:
The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is an N-protecting group; n is 0 or 1; B is hydrogen, hydroxy, NH, loweralkyl or arylalkyl; with the proviso that when A is an N-protecting group, B is NH and when n is 0, B is hydrogen, hydroxy, loweralkyl or arylalkyl; R.sub.1, R.sub.3 and R.sub.5 are loweralkyl or hydrophilic, lipophilic or aromatic amino acid side chains and may be the same or different; R.sub.2, R.sub.4, R.sub.7, R.sub.8 and R.sub.9 are hydrogen or loweralkyl and may be the same or different; X is NH, O, S, SO or SO.sub.2 ; and R.sub.6 is loweralkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or an N-protecting group, with the proviso that R.sub.6 may be an N-protecting group when X is NH.

REFERENCES:
patent: 4384994 (1983-05-01), Veber et al.
patent: 4424207 (1984-01-01), Szelke et al.
Kokubu et al., Biochemical and Biophysical Research Communications, 118, No. 3, 929-933, (1984).
Evin et al., Proceedings in the Eights American Peptide Symposium, 583-586, (1984).
Johnson et al., J. Med. Chem., 23, 666-669, (1980).
Rudinger, Peptide Hormones, Parsons (ed.), U. Park Press, Baltimore, (1976), pp. 1-7.

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