Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-02-14
1993-04-20
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514332, 514333, 514334, 514335, 514337, 514338, 514340, 514342, 514343, 514346, 514347, 514348, 514349, 514350, 514351, 514352, 514354, 514355, 514356, 514357, 546146, 546147, 546256, 546257, 546258, 546261, 546270, 546274, 546278, 546291, 546292, 546293, 546294, 546296, 546297, 546298, 546299, 546300, 546304, 546307, 546308, 546309, 546310, 546311, 546312, 546330, 546331, 546334, 546335, 546336, 546337, A61K 3144, A61K 3147, C07D40104, C07D40106, C07D21182, C07D21184, C07D21186
Patent
active
052043576
ABSTRACT:
The invention relates to compounds of the formula I ##STR1## in which A represents a substituted thio-, sulfinyl- or sulfonyl-alkanoyl radical or a four- to eleven-membered heterocycle, B is an amino acid residue, R.sup.1 denotes hydrogen (substituted) alkyl, (substituted)cycloalkyl or aryl, R.sup.2 represents hydrogen, (substituted)alkyl or aryl, R.sup.3 denotes a radical of the formula --(CH.sub.2).sub.q --(X).sub.r --(CH.sub.2).sub.s --R.sup.6 with X denoting CF.sub.2, CO or CHR.sup.8, R.sup.6 denoting a (substituted)heteroaromatic, R.sup.8 denoting alkyl, alkoxy, alkylthio, alkylamino, hydroxyl, azide or halogen, q and s denoting 1 to 4, and r denoting 0 or 1, and R.sup.9 is hydrogen, (substituted)alkyl, alkanoyl, cycloalkanoyl, (substituted) aroyl or (substituted)aryl, and to the salts thereof. In addition, processes for the preparation of these compounds, and the use thereof as renin inhibitors are described.
REFERENCES:
Burger, A. Medicinal Chemistry, 2nd Ed. pp. 565-601 (1960).
Haber et al.; J. of Cardiovascular Pharm. pp. 554-558 (1987).
Denkewalter et al. Progress in Drug. Research, pp. 510-512 (1966).
Bolis et al. Renin Inhibitors, J. Medicinal Chemistry, vol. 30, No. 10, pp. 1729-1737 (1987).
Plattner et al.; J. Medicinal Chem. vol. 31, No. 12, pp. 2277-2288 (1988).
Browne et al. Chem. Abstracts vol. 111; 58354v (1989).
Henning Rainer
Ruppert Dieter
Scholkens Bernward
Urbach Hansjorg
Hoechst Aktiengesellschaft
Richter Johann
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