Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1999-10-13
2000-12-12
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435188, 53038826, C12N 996, C12N 964, C07K 1600, C12P 2108
Patent
active
061597236
ABSTRACT:
Disclosed is a novel renin-active substance by utilizing a anti-peptide antibody capable of specifically recognizing a specific amino acid sequence in the human propenin profragment exemplified, as a typical example, by a complex formed from human prorenin and an anti-peptide antibody capable of specifically recognizing an amino acid sequence consisting of at least 15 amino acid residues located within an amino acid sequence consisting of 33 amino acid residues between the isoleucine residue at the 11th site and the arginine residue at the 43rd site within human propenin profragment having an amino acid sequence consisting of 43 amino acid residues.
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F. H. M. Derkx et al., Journal of Biological Chemistry, 267 (32) 22837-42 (Nov. 15, 1992).
Patent Abstracts of Japan, vol. 010, No. 364 (P-524), Dec. 5, 1986, abstract of JP 61 160058 A.
Suzuki et al., Bioscience Biotechnology and Biochemistry, vol. 63, No. 3, pp. 550-554 (Mar. 1999).
Ishizuka et al.-Characterization of MAbS Against Human Prorenir Proeragment & ID of Active Prorenins in Plasma. J Biochem 106:430-435, 1989.
Paul et al.-Fundamental Immunology, 4th Ed. pp. 107 & 657, 1999.
Ishida Yuichi
Murakami Kazuo
Nakamura Yukio
Suzuki Fumiaki
Chan Christina Y.
Ewoldt Gerald R.
Ishida Yuichi
Tokiwa Chemical Industries, Ltd.
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