Renal dilating methods and compositions using 4-(3,4-dihydroxyph

Details Renal dilating methods and compositions using 4-(3,4-dihydroxyph Renal dilating methods and compositions using 4-(3,4-dihydroxyph

1980-05-22

1982-07-20

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546143, 546144, A61K 3147, C07D21716

Patent

active

043406009

ABSTRACT:
4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2-substituted benzyl)-1-(3,4-dimethoxyphenyl)-aminoethanol using either a Lewis acid or an acid cyclizing agent followed by demethylation at the 3,4-dimethoxyphenyl moiety.

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patent: 3872125 (1975-03-01), Houlihan et al.
patent: 4185105 (1980-01-01), Schmitt et al.
Bobbitt, et al., "J. Org. Chem.", vol. 35, No. 4, 1970, pp. 1181-1183.
Woodruff et al., "Peripheral Dopamine Receptors, Proc. of Satellite Symp. of 7th Intl. Congress of Pharmacology", 1978, pp. 57-70.
Costall et al., "J. Pharm. Pharmac", vol. 30, 1978, pp. 514-516.
Woodruff, "Br. J. Clin. Pharm.", Suppl. 2, vol. 4, p. 1055.
Poat et al., "J. Pharm. Pharmac", vol. 30, p. 495.
Freter et al., "J. Hetero. Chem.", vol. 7, 1970, pp. 159-169.

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