Removal of heparin from heparin-containing blood plasma samples

Details Removal of heparin from heparin-containing blood plasma samples Removal of heparin from heparin-containing blood plasma samples

1979-06-20

1980-10-07

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

536 21, G01N 3100

Patent

active

042265991

ABSTRACT:
A tableted form of fibrous triethylaminoethyl cellulose suitable for the removal of heparin from heparin-containing blood plasma. The tablet is composed of granular microcrystalline cellulose and fibrous triethylaminoethyl cellulose in a ratio of from about 5.4:1 to about 10:1. The triethylaminoethyl cellulose tablet, which is formulated to provide from about 5 to about 26 mg. of triethylaminoethyl cellulose per milliliter of plasma sample, is added to a heparin-containing blood plasma sample, the sample is agitated or allowed to stand for a time sufficient to permit adsorption of substantially all heparin present. The sample is then centrifuged and the remaining heparin-free plasma can be subjected to coagulation testing in order to determine the true clotting time.

REFERENCES:
patent: 2128432 (1938-08-01), Ramage
patent: 2687990 (1954-08-01), Weisz
patent: 3099600 (1963-07-01), Toccaceli
patent: 4055510 (1977-10-01), Peska
patent: 4122250 (1978-10-01), Schmer
Chemical Abstracts, 78:112325b (1973).
Nealon et al., "An Extracorporeal Device to Treat Barbiturate Poisoning," JAMA, Jul. 1966, vol. 197, No. 2, 158-160.
Thompson et al., "Removal of Heparin and Protamine from Plasma," J. Lab. Clin. Med., 88, 922-929 (Dec. 1976).

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