Chemistry: analytical and immunological testing – Biospecific ligand binding assay – Utilizing isolate of tissue or organ as binding agent
Reexamination Certificate
2006-06-27
2006-06-27
Gakh, Yelena G. (Department: 1743)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
Utilizing isolate of tissue or organ as binding agent
C436S518000, C435S040500, C435S040520
Reexamination Certificate
active
07067325
ABSTRACT:
The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The reagents comprise components optimized to facilitate removal or etching of the embedding media from the biological sample. The present invention also provides reagents for use in an automated environment for cell conditioning biological samples wherein the cells are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The reagents comprise components optimized to facilitate molecular access to cells and cell constituents within the biological sample.
REFERENCES:
patent: 4043292 (1977-08-01), Rogers et al.
patent: 4384193 (1983-05-01), Kledzik et al.
patent: 4543236 (1985-09-01), von Gise
patent: 4629862 (1986-12-01), Kitagawa et al.
patent: 4644807 (1987-02-01), Mar
patent: 4746491 (1988-05-01), Ohlin
patent: 4858155 (1989-08-01), Okawa et al.
patent: 4865986 (1989-09-01), Coy et al.
patent: 4888998 (1989-12-01), Buzza et al.
patent: 5023187 (1991-06-01), Koebler et al.
patent: 5075079 (1991-12-01), Kerr et al.
patent: 5187099 (1993-02-01), Healy et al.
patent: 5244787 (1993-09-01), Key et al.
patent: 5273905 (1993-12-01), Muller et al.
patent: 5318795 (1994-06-01), Stokes et al.
patent: 5344637 (1994-09-01), Camiener
patent: 5417123 (1995-05-01), D'Autry
patent: 5439649 (1995-08-01), Tseung et al.
patent: 5487975 (1996-01-01), Miller et al.
patent: 5595707 (1997-01-01), Copeland et al.
patent: 5601141 (1997-02-01), Gordon et al.
patent: 5614376 (1997-03-01), Copley et al.
patent: 5645144 (1997-07-01), Schaefers et al.
patent: 5672696 (1997-09-01), Wang et al.
patent: 5695942 (1997-12-01), Farmilo et al.
patent: 5948359 (1999-09-01), Kalra et al.
patent: 5965454 (1999-10-01), Farmilo et al.
patent: 6544798 (2003-04-01), Christensen et al.
patent: 1059744 (1979-08-01), None
patent: 1279273 (2001-01-01), None
patent: 0 508 568 (1992-10-01), None
patent: WO 93/09486 (1993-05-01), None
patent: WO 94/04906 (1994-03-01), None
patent: WO 95/24498 (1995-09-01), None
patent: WO 01/88500 (2001-11-01), None
Yörüko{hacek over (g)}lu et al. “Epitope Retrieval Technique: a Sample Modification that Reduces Staining Time”, Applied Immunohistochemistry, 1997, 5(1), 71.
Bankfalvi, A. et al. (1994) “Wet autoclaving pretreatment for antigen retrieval in diagnostic immunohistochemistry.”Journal of Pathology174: 223-228.
Fox, C.H. et al. (1985) “Formaldehyde fixation.”Journal of Histochemistry and Cytochemistry33(8): 845-853.
Kawai, K. et al. (1994) “Heat-induced antigen retrieval of proliferating cell nuclear antigen and p53 protein in formalin-fixed, paraffin-embedded sections.”Pathology International44: 759-764.
Mason, J.T. & O'Leary, T.J. (1991) “Effects of formaldehyde fixation on protein secondary structure: a calorimetric and infrared spectroscopy investigation.”Journal of Histochemistry and Cytochemistry39 (2): 225-229.
MaWhinny, W.H.B. et al. (1990) “Automated immunohistochemistry.”Journal of Clinical Pathology43: 591-596.
McNicol, A.M. & Richmond, J.A. (1998) “Optimizing immunohistochemistry: antigen retrieval and signal amplification.”Histopathology32: 97-103.
Miller, R.T. & Estran, C. (1995) “Heat-induced epitope retrieval with a pressure cooker.”Applied Immunohistochemistry3(3): 190-193.
Morgan, J.M. et al. (1994) “Possible role of tissue-bound calcium ions in citrate-mediated high-temperature antigen retrieval.”Journal of Pathology174: 301-307.
Norton, A.J. et al. (1994) “Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues.”Journal of Pathology173: 371-379.
Pasha, T. et al. (1995) “Nuclear antigen retrieval utilizing steam heat.”Laboratory Investigations72: 167A, abstract #979.
Pertschuk, L.P. et al. (1994) “Estrogen receptor immunocytochemistry: the promise and the perils.”Journal of Cellular Biochemistrysuppl. 19: 134-137.
Pons, C. et al. (1995) “Antigen retrieval by wet autoclaving for p53 immunostaining.”Applied Immunohistochemistry3(4): 265-267.
Shi, S.-R. et al. (1997) “Antigen retrieval immunohistochemistry: past, present, and future.”Journal of Histochemistry and Cytochemistry45 (3): 327-343.
Sibony, M. et al. (1995) “Methods in laboratory investigation: Enhancement of mRNAin situhybridization signal by microwave heating.”Laboratory Investigation73 (4): 586-591.
Sperry, A. et al. (1996) “Microwave treatment enhances detection of RNA and DNA by in situ hybridization.”Diagnostic Molecular Pathology5 (4): 291-296.
Stark, E. et al. (1998) “An automated device for immunohistochemistry.”Journal of Immunological Methods107: 89-92.
Stross, W.P. et al. (1989) “Automation of APAAP immuncytochemical technique.”Journal of Clinical Pathology42: 106-112.
Taylor, C.R. et al. (1995) “A comparative study of antigen retrieval heating methods.”CAP Today9: 16-22.
International Search Report for application PCT/US99/20353.
International Search Report for application PCT/US99/04379.
International Search Report for application PCT/US99/04181.
Lyon, et al., “Non-hazardous organic solvents in the paraffin-embedding technique: a rational approach. Aliphatic monoesters for clearing and dewaxing: butyldecanoate,” Histochem Cell Biol, 103:4, pp. 263-269, Apr. 1995.
Shi, et al., “Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections,” J Histochem Cytochem, 41:11, pp. 1599-1604, Nov. 1993.
No author, “Cell Diagnostics round up: xylene alternatives,” UK press release by Merck UK, Aug. 14, 1998.
Falkeholm, et al., “Xylene-free method for histological preparation: a multicentre evaluation,” Lab Invest, vol. 81, pp. 1213-1221, Sep. 2001.
Ziehl-Neelsen Stain for AFB Article, 3 pages: http://medlib.med,utah.edu/WebPath/HISTHTML/MANUAL/ZIEHL.PDF (Aug. 3, 1999).
Christensen Kimberly
Macrea Ethel
Sebastiao Noemi
Gakh Yelena G.
McDonnell Boehnen & Hulbert & Berghoff LLP
Ventana Medical Systems, Inc.
LandOfFree
Removal of embedding media from biological samples and cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Removal of embedding media from biological samples and cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Removal of embedding media from biological samples and cell... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3675274