Removal of bilirubin by the pseudoperoxidase activity of immobil

Details Removal of bilirubin by the pseudoperoxidase activity of immobil Removal of bilirubin by the pseudoperoxidase activity of immobil

1987-09-10

1989-04-11

Jones, W. Gary

Liquid purification or separation

Processes

Treating by enzyme

210759, 210763, 435 25, 435 28, 435264, 435269, 436 97, 436178, B01D 1500, B01D 4300

Patent

active

048204161

ABSTRACT:
The present invention relates to a process for oxidizing bilirubin which comprises reacting a solution containing bilirubin with hemoglobin, either in free or immobilized form, in the presence of an oxidizing agent such as hydrogen peroxide. This process if useful in reducing bilirubin levels in the blood of severely jaundiced patients. It also provides a basis for determining bilirubin levels in a fluid.

REFERENCES:
patent: 4563429 (1986-01-01), Doumas et al.
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Chang, T. M. S., Artificial Cells Containing Multienzyme Systems, (1985), Meth. Enzymol., 112, 195-203.
Chang, T. M. S., Applications of Artificial Cells in Medicine and Biotechnology, (1987), Biomat. Art. Cells Org., 15(1), 1-20.
Sideman S. et al., Preparation of a Biocompatible Albumin-Coated Iron Exchange Resin for Bilirubin Removal from the Blood of Jaundiced Newborns, (1983), J. Biomed. Mat. Res., 17, 91-107.
Keipert P. et al., Cross-Linked Stroma-Free Polyhemoglobin as a Potential Blood Substitute, Int. J. Artif. Org., vol. 5, 383-385, (1982).
Sung C. et al., An Immobilized Enzyme Reactor for the Detroxification of Bilirubin, (1986), Biotech. and Bioeng., vol. 27, 1531-1539.
Keipert P. et al., Preparation and in vitro Characteristics of a Blood Substitute Based on Pyridoxylated Polyhemoglobin, (1984), Appl. Biochem. and Biotech., vol. 10, 133-141.

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