Removal of antibodies from blood-derived compositions while reta

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530381, 530382, 530383, 530384, 530412, 530413, 530417, 525 541, 2101982, 210645, 210651, 210656, C07K 100, B01D 6100

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055412947

ABSTRACT:
This invention relates to methods of removing undesired antibodies from blood-derived compositions containing both the antibodies and coagulation factors, such that the coagulation factors are substantially retained in the composition. The undesired antibodies may be blood group antibodies. This invention also relates to compositions in which undesired antibodies have been removed and desired coagulation factors are retained. This invention further relates to methods of inactivating virus and removing undesired antibodies from blood-derived compositions containing virus, antibodies and coagulation factors without removing coagulation factors therefrom, and to the resulting compositions.

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"Virus-Free Protein Containing Composition Preparation Obtained By Treatment With Trialkylphosphates Followed By Affinity Chromatography", Derwent Publications Ltd., Jul. 13, 1990.
"Virus Free Protein Containing Composition Preparation" by Derwent.
Theodorsson et al, Blood, vol. 61, No. 5, pp. 973-981, May 1983.
Lieburou et al, Proc. Natl. Acad. Sci. USA, vol. 82, pp. 3879-3883, Jun. 1985.
Tharakau et al, Journal of Chromatography, vol. 595, pp. 103-111, 1992.

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