Removable drug implant

Details Removable drug implant Removable drug implant

1978-09-22

1980-03-04

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

128260, 424 28, 424 78, A61M 700, A61K 2712, A61K 900, A61K 952

Patent

active

041917413

ABSTRACT:
There is disclosed an implant which has an inert, biocompatible core with a coating comprising from about 5 to about 40% of estradiol in a biocompatible dimethylpolysiloxane rubber. When the implant is placed under the skin of a ruminant animal the estradiol is released at a substantially constant rate to produce a greater than normal weight gain in the animal. The implant remains intact and may be removed from the animal at the end of the desired period of drug administration.

REFERENCES:
patent: Re28536 (1975-09-01), Reed
patent: 3279996 (1966-10-01), Long et al.
patent: 3499445 (1970-03-01), Reed
patent: 3545439 (1970-12-01), Duncan
patent: 3920805 (1975-11-01), Roseman
patent: 3946106 (1976-03-01), Chien et al.
patent: 3992518 (1976-11-01), Chien et al.
patent: 4012496 (1977-03-01), Schopflin
patent: 4012497 (1977-03-01), Schopflin
patent: 4053580 (1977-10-01), Chien et al.
patent: 4096239 (1978-06-01), Katz et al.
Cooney, Al ChE Journal, May 1971, pp. 754-756, Slow Dissolution of Implanted Beds of Spherical Particles as a Method for Prolonged Release Medication, ("Medicine Compounded on an Inert Core").

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