Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2006-10-07
2009-08-04
Berman, Jack I. (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000, C250S283000, C250S288000, C250S294000, C435S004000, C435S006120, C435S287100, C435S287200, C435S040500, C435S071100
Reexamination Certificate
active
07569812
ABSTRACT:
An improved ion source and means for collecting and focusing dispersed gas-phase ions from a remote reagent chemical ionization source (R2CIS) at atmospheric or intermediate pressure is described. The R2CIS is under electronic control and can produce positive, negative, or positive and negative reagent ions simultaneously. This remote source of reagent ions is separated from a low-field sample ionization region by a stratified array of elements, each element populated with a plurality of openings, wherein DC potentials are applied to each element necessary for transferring reagent ions from the R2CIS into the low-field sample ionization region where the reagent ions react with neutral and/or ionic sample forming sample ionic species. The resulting sample ionic species are then introduced into a mass spectrometer, ion mobility spectrometer or other sensor capable of detecting the sample ions. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when gas and liquid chromatographic separation techniques are coupled to atmospheric and intermediate pressure photo-ionization, chemical ionization, and thermospray ionization sources; and improving the sensitivity of chemical detectors or probes.
REFERENCES:
patent: 4000918 (1977-01-01), Reker
patent: 4159423 (1979-06-01), Kambara
patent: 4209696 (1980-06-01), Fite
patent: 4271357 (1981-06-01), Bradshaw et al.
patent: 4300004 (1981-11-01), Wissner et al.
patent: 4318028 (1982-03-01), Perel et al.
patent: 4468468 (1984-08-01), Benninghoven et al.
patent: 4531056 (1985-07-01), Labowsky et al.
patent: 4542293 (1985-09-01), Fenn et al.
patent: 4546253 (1985-10-01), Tsuchiya et al.
patent: 4789783 (1988-12-01), Cook
patent: 4855595 (1989-08-01), Blanchard
patent: 4948962 (1990-08-01), Mitsui et al.
patent: 4974648 (1990-12-01), Propst
patent: 4976920 (1990-12-01), Jacob
patent: 4977320 (1990-12-01), Chowdhury et al.
patent: 4999492 (1991-03-01), Nakagawa
patent: 5141532 (1992-08-01), Sacks et al.
patent: 5142143 (1992-08-01), Fite et al.
patent: 5164704 (1992-11-01), Steen et al.
patent: 5168068 (1992-12-01), Yanagisawa et al.
patent: 5171525 (1992-12-01), Jacob
patent: 5192865 (1993-03-01), Zhu
patent: 5280175 (1994-01-01), Karl
patent: 5304797 (1994-04-01), Irie et al.
patent: 5305015 (1994-04-01), Schantz et al.
patent: 5306910 (1994-04-01), Jarrell et al.
patent: 5338931 (1994-08-01), Spangler et al.
patent: 5412208 (1995-05-01), Covey et al.
patent: 5412209 (1995-05-01), Otaka et al.
patent: 5436446 (1995-07-01), Jarrell et al.
patent: 5485016 (1996-01-01), Irie et al.
patent: 5541519 (1996-07-01), Stearns et al.
patent: 5559326 (1996-09-01), Goodley et al.
patent: 5581081 (1996-12-01), Kato et al.
patent: 5587581 (1996-12-01), Stroosnyder
patent: 5625184 (1997-04-01), Vestal et al.
patent: 5684300 (1997-11-01), Taylor et al.
patent: 5736740 (1998-04-01), Franzen
patent: 5747799 (1998-05-01), Franzen
patent: 5750988 (1998-05-01), Apffel et al.
patent: 5753910 (1998-05-01), Gourley et al.
patent: 5756994 (1998-05-01), Bajic
patent: 5798146 (1998-08-01), Murokh et al.
patent: 5828062 (1998-10-01), Jarrell et al.
patent: 5838002 (1998-11-01), Sheehan
patent: 5873523 (1999-02-01), Gomez et al.
patent: 5892364 (1999-04-01), Monagle
patent: 5945678 (1999-08-01), Yanagisawa
patent: 5965884 (1999-10-01), Laiko et al.
patent: 5986259 (1999-11-01), Hirabayashi et al.
patent: 6040575 (2000-03-01), Whitehouse et al.
patent: 6060705 (2000-05-01), Whitehouse et al.
patent: 6107628 (2000-08-01), Smith et al.
patent: 6124675 (2000-09-01), Bertrand et al.
patent: 6147345 (2000-11-01), Willoughby
patent: 6204500 (2001-03-01), Whitehouse et al.
patent: 6207954 (2001-03-01), Andrien, Jr. et al.
patent: 6223584 (2001-05-01), Mustacich et al.
patent: 6225623 (2001-05-01), Turner et al.
patent: 6239428 (2001-05-01), Kunz
patent: 6278111 (2001-08-01), Sheehan et al.
patent: 6359275 (2002-03-01), Bertsch et al.
patent: 6455846 (2002-09-01), Prior et al.
patent: 6462338 (2002-10-01), Inatsugu et al.
patent: 6465776 (2002-10-01), Moini et al.
patent: 6486469 (2002-11-01), Fischer et al.
patent: 6495823 (2002-12-01), Miller et al.
patent: 6512224 (2003-01-01), Miller et al.
patent: 6534765 (2003-03-01), Robb et al.
patent: 6537817 (2003-03-01), Papen
patent: 6583407 (2003-06-01), Fischer et al.
patent: 6583408 (2003-06-01), Smith et al.
patent: 6600155 (2003-07-01), Andrien, Jr. et al.
patent: 6610986 (2003-08-01), Hartley
patent: 6649907 (2003-11-01), Ebeling et al.
patent: 6683301 (2004-01-01), Whitehouse et al.
patent: 6690004 (2004-02-01), Miller et al.
patent: 6727496 (2004-04-01), Miller et al.
patent: 6744041 (2004-06-01), Sheehan et al.
patent: 6750449 (2004-06-01), Marcus
patent: 6784424 (2004-08-01), Willoughby et al.
patent: 6815668 (2004-11-01), Miller et al.
patent: 6818889 (2004-11-01), Sheehan et al.
patent: 6822225 (2004-11-01), Xu et al.
patent: 6852969 (2005-02-01), Marcus et al.
patent: 6852970 (2005-02-01), Yamada et al.
patent: 6867415 (2005-03-01), Hughey et al.
patent: 6878930 (2005-04-01), Willoughby et al.
patent: 6888132 (2005-05-01), Sheehan et al.
patent: 6914243 (2005-07-01), Sheehan et al.
patent: 6943347 (2005-09-01), Willoughby et al.
patent: 6949740 (2005-09-01), Sheehan et al.
patent: 6949741 (2005-09-01), Cody et al.
patent: 6972407 (2005-12-01), Miller et al.
patent: 6998605 (2006-02-01), Frazer et al.
patent: 7005634 (2006-02-01), Shiokawa et al.
patent: 7041966 (2006-05-01), Frazer et al.
patent: 7053367 (2006-05-01), Tobita et al.
patent: 7060976 (2006-06-01), Sheehan et al.
patent: 7064320 (2006-06-01), Yamada et al.
patent: 7078068 (2006-07-01), Book
patent: 7083112 (2006-08-01), Ivri
patent: 7087898 (2006-08-01), Willoughby et al.
patent: 7091493 (2006-08-01), Hiraoka
patent: 7095019 (2006-08-01), Sheehan et al.
patent: 7112785 (2006-09-01), Laramee et al.
patent: 7112786 (2006-09-01), Russ, IV et al.
patent: 7138626 (2006-11-01), Karpetsky
patent: 7253406 (2007-08-01), Sheehan et al.
patent: 7259368 (2007-08-01), Frazer et al.
patent: 7274015 (2007-09-01), Miller et al.
patent: 7429731 (2008-09-01), Karpetsky
patent: 2002/0011560 (2002-01-01), Sheehan et al.
patent: 2002/0175278 (2002-11-01), Whitehouse
patent: 2002/0185593 (2002-12-01), Doring
patent: 2002/0185595 (2002-12-01), Smith et al.
patent: 2003/0034452 (2003-02-01), Fischer et al.
patent: 2003/0038236 (2003-02-01), Russ, IV et al.
patent: 2003/0197121 (2003-10-01), Turecek et al.
patent: 2004/0161856 (2004-08-01), Handly
patent: 2004/0245458 (2004-12-01), Sheehan et al.
patent: 2005/0056775 (2005-03-01), Cody et al.
patent: 2005/0196871 (2005-09-01), Cody et al.
patent: 2006/0249671 (2006-11-01), Karpetsky
patent: 2007/0084999 (2007-04-01), Miller et al.
patent: 2007/0114389 (2007-05-01), Karpetsky et al.
patent: 2008/0296493 (2008-12-01), Willoughby et al.
patent: 2127212 (1984-04-01), None
patent: 2288061 (1995-10-01), None
patent: 04215329 (1992-08-01), None
patent: 05203637 (1993-08-01), None
patent: 10088798 (1998-04-01), None
patent: WO 93/14515 (1993-07-01), None
patent: WO 98/07505 (1998-02-01), None
patent: WO 99/63576 (1999-12-01), None
patent: WO 00/08455 (2000-02-01), None
patent: WO 00/08456 (2000-02-01), None
patent: WO 00/08457 (2000-02-01), None
patent: WO 01/33604 (2001-05-01), None
patent: WO 01/33605 (2001-05-01), None
patent: WO 03/010794 (2003-02-01), None
patent: WO 04/098743 (2004-11-01), None
patent: WO 04/110583 (2004-12-01), None
patent: WO 06/011171 (2006-02-01), None
patent: WO 06/122121 (2006-11-01), None
patent: WO 08/054393 (2008-05-01), None
Hanson, Eric, “How an Ink Jet Printer Works” [online], [retrieved on May 15, 2008], 5 pp., Retrieved from Internet:http://www.imaging.org/resources/web—tutorials/inkjet—files/inkjet.cfm.
Le, Hue P., “Progress and Trends in Ink-Jet Printing Technology” [online],Journal of Imaging Science and Technology,vol. 42, No. 1, Jan./Feb., 1998 [retrieved on May 15, 2008], pp, Retrieved from the Internet:http://www.imaging.org/resources/web—tutorials/inkjet.cfm.
Chemi-Ionization-Mass Spectrometry Terms,
Berends, Jr. John C.
Karpetsky Timothy P.
Sheehan Edward W.
Willoughby Ross C.
Berman Jack I.
King & Spalding LLP
Sahu Meenakshi S
Science Applications International Corporation
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