Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1995-05-08
1997-02-25
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 49, 424 57, A61K 716, A61K 718
Patent
active
056056770
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP93/02291 filed Oct. 28, 1993.
FIELD OF THE INVENTION
This invention relates to dental care preparations which have a restoring effect on the surface of teeth and to a process for restoring the surface of teeth.
BACKGROUND OF THE INVENTION
Dental care preparations are mainly used to remove food remains, dicoloration and firmly adhering bacterial coatings from the surface of teeth. In addition, attempts have been made to prevent dental diseases, such as caries or parodontosis, by incorporation of special additives, for example fluorine compounds or antimicrobial agents.
RELATED ART
Lesions in the dental enamel and open dentinal canals (so-called Tomes pits) are observed as one of the first signs of dental caries, being caused by dissolving processes under the influence of acid-forming bacteria. This damage to the dentinal substance is reflected, for example, in sensitivity in the necks of teeth to variations in temperature. Whereas additions of desensitizing agents can only control the painful symptoms, attempts have already been made to prevent the formation of the surface lesions in question by the incorporation of additives which reduce apatite solubility. Proposals have also recently been made to reduce existing damage by the use of remineralizing dental care preparations. Thus, Chow and Brown (J. Dent. Res., 54, (1975), 65-70) proposed the use of dicalcium phosphate dihydrate to remineralize the dentine. U.S. Pat. No. 4,097,588 describes a remineralizing mouthwash saturated with CaHPO.sub.4.2H.sub.2 O.
However, hitherto known efforts to restore the surface of teeth in this way have resulted in the uncontrolled growth of hydroxyl apatite crystals on the surface of the teeth which offers little resistance to further attacks on the surface of the teeth. Accordingly, the problem addressed by the present invention was to develop a toothpaste which would provide for controlled remineralization, particularly in scratch marks and dentinal canals, and would make these areas substantially level, so that the teeth would be left with a smooth continuous surface.
It has been found that this problem has been solved to a large extent by the combination of polishes according to the invention.
BRIEF SUMMARY OF THE INVENTION
The present invention relates to a toothpaste for restoring the surface of the teeth containing polishes, fluorine compounds, humectants, binders and water, characterized in that it contains a combination of silica and dicalcium phosphate dihydrate (brushite) in a ratio by weight of 10:1 to 1:1 as the polishing component. It has been found that regular brushing of the teeth with the toothpaste according to the invention results in the closure of dentinal canals so that the surface of the teeth is restored to a substantially smooth condition.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1: A scanning electron micrograph of human enamel, untreated
FIG. 2: A scanning electron micrograph of human dentine, untreated
FIG. 3: A scanning electron micrograph of human enamel, treated with comparison toothpaste C
FIG. 4: A scanning electron micrograph of human dentine, treated with comparison toothpaste C
FIG. 5: A scanning electron micrograph of human enamel treated with the toothpaste of Example 1. It can be seen that hydroxyl apatite has precipitated in the surface scratches.
FIG. 6: A scanning electron micrograph of human dentine treated with the toothpaste of Example 1. The substantial closure of the dentinal canals by precipitated hydroxyl apatite can clearly be seen.
DETAILED DESCRIPTION OF THE INVENTION
Any gel silicas, hydrogel silicas and precipitated silicas known as polishes are suitable for use as the silica polish. Gel silicas are obtained by reaction of sodium silicate solutions with strong aqueous mineral acids to form a hydrosol, ageing to form a hydrogel, washing and drying. If drying is carried out under moderate conditions to water contents of 15 to 35% by weight, the so-called hydrogel silicas known, for example, from U.S. Pat. No. 4,153,680 ar
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J. Dent. Res., 54, (1975), 65-70 Chow DPD.
Foerg Franz
Laska Hans
Schumann Klaus
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Ortiz Daniel S.
Rose Shep K.
Szoke Ernest G.
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