Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-02-24
1998-05-12
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514252, 514404, 514444, 514445, 514608, 514824, A61K 3150, A61K 31495, A61K 31415, A61K 3138, A61K 3116
Patent
active
057505241
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/JP95/01486, filed Jul. 26, 1995.
TECHNICAL FIELD
The present invention relates to a remedy for hyperlipidemia, and more particularly to a remedy for hyperlipidemia, which reduces both cholesterol and triglycerides.
BACKGROUND ART
Hyperlipidemia is a morbid state in which lipids (cholesterol and triglycerides) in plasma increase, and the object of treatment for the hyperlipidemia is to prevent arteriosclerotic diseases such as myocardial infarction, cerebral infarction, occlusion of peripheral artery and arteriosclerosis.
In the past, clofibrate type medicines and HMG-CoA reducdase inhibitors have been clinically used for the prevention of and treatment for the hyperlipidemia. However, they cannot be always said to be satisfactory from the viewpoint of the prevention of and treatment for the arteriosclerotic diseases.
DISCLOSURE OF THE INVENTION
The present inventors have carried out various investigations with a view toward solving the above problems. As a result, it has been found that some indane derivatives have an effect of reducing lipids in blood, thus leading to completion of the present invention.
According to the present invention, there is thus provided a remedy for hyperlipidemia, comprising, as an active ingredient, an indane derivative represented by the following general formula (1): ##STR3## wherein R.sup.1 means an alkyl group having 1-12 carbon atoms, a benzyl group, a styryl group, a naphthyl group, a phenyl group which may be substituted, or a thienyl group which may be substituted, R.sup.2 denotes a carboxyl group, an alkoxycarbonyl group having 1-4 carbon atoms, ##STR4## Y is a group represented by --CH.sub.2).sub.p -- (p stands for an integer of 0-5), a group represented by --CO--CH.sub.2).sub.q .about. or --CH(OH)--CH.sub.2).sub.q .about. (q stands for an integer of 1-4, and .about. means bonding to R.sup.2), an oxymethylene group, or a vinylene group, and n stands for an integer of 1-4, or a pharmaceutically acceptable salt thereof.
According to the present invention, there is also provided use of the indane derivative (1) or the pharmaceutically acceptable salt thereof for the preparation of a remedy for hyperlipidemia.
According to the present invention, there is further provided a method for treating hyperlipidemia, which comprises administering an effective amount of the indane derivative (1) or the pharmaceutically acceptable salt thereof to a patient of hyperlipidemia.
BEST MODE FOR CARRYING OUT THE INVENTION
represented by the general formula (1), which is an active ingredient of the remedy for hyperlipidemia, is a known compound disclosed in International Publication No. WO92/15558 and is known to strongly antagonize the effect of thromboxane A.sub.2 and have an effect of inhibiting platelet agglutination, but is not known to have an effect of reducing lipids in blood.
In the general formula (1), examples of "the phenyl group which may be substituted" include phenyl groups substituted by one or two alkyl groups having 1-8 carbon atoms, alkoxy groups having 1-4 carbon atoms, trifluoromethyl groups, trifluoromethoxy groups, nitro groups, amino groups, nitrile groups or halogen atoms, and a phenyl group having no substituent. Examples of "the thienyl group which may be substituted" include thienyl groups substituted by one or two alkyl groups having 1-8 carbon atoms, alkoxy groups having 1-4 carbon atoms, phenylsulfonyl groups, halogen atoms or trifluoromethyl groups, and a thienyl group having no substituent.
R.sup.1 is preferably a benzyl group, a styryl group, a naphthyl group, a phenyl group which may be substituted, or a thienyl group which may be substituted. Of these, the phenyl group which may have a substituent is more preferred, with the phenyl group substituted by one or two halogen atoms being particularly preferred.
Examples of R.sup.2 include a carboxyl group, alkoxycarbonyl groups having 1-4 carbon atoms, a 3-oxo-2,3,4-trihydropyrazol-5-yl group and a 3-oxo-2,3,4,5-tetrahydropyridazin-6-yl. Of these, the carboxy group
REFERENCES:
CA 118:191362, Yoshida et al., 1992.
Kurimoto Tadashi
Mera Yukinori
Nishi Naoki
Sato Hiroki
Jordan Kimberly
Zeria Pharmaceutical Co. Ltd.
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