Remedy for chronic disease

Details Remedy for chronic disease Remedy for chronic disease

2007-11-27

2007-11-27

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S106000

Reexamination Certificate

active

10519106

ABSTRACT:
A remedy and/or a preventive for a chronic disease which contains an EDG-2 antagonist. Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and/or preventing chronic diseases (for example, diseases caused by the progress of chronic asthma, glomerular nephritis, obesity, arteriosclerosis, rheumatoid and atopic diseases) induced and made chronic by tissue cells whose proliferation is accelerated by LPA mediated by EDG-2.

REFERENCES:
patent: 2004/0067908 (2004-04-01), Nakade et al.
patent: 2004/0167132 (2004-08-01), Shankar et al.
patent: 2004/0171582 (2004-09-01), Nakade et al.
patent: 2004/0224941 (2004-11-01), Seko et al.
patent: 2005/0256160 (2005-11-01), Habashita et al.
patent: 2006/0148830 (2006-07-01), Terakado et al.
patent: WO 01/60819 (2001-08-01), None
patent: WO 01/71022 (2001-09-01), None
patent: WO 03/101978 (2003-12-01), None
Contos et al. “Lysophosphatidic Acid Receptors,” Mol. Pharm., 2000, 58, 1188-96.
Pages et al. “Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading,” J. Biol. Chem., 2001, 276, 11599-05.
Adolfsson et al. “Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: sildenafil and papaverin generate inhibition,” Prost., 2002, 51, 50-8.
Vacherot et al., “Induction of apoptosis and inhibition of cell proliferation by the lipido-sterolic extract of Serenoa repens (LSESr, Permixon in benign prostatic hyperplasia,” Prost., 2000, 45, 259-66.
Dixon “Weight loss medications,” Austr. Fam. Phys., 2006, 35, 576-9.
Rindfleisch et al. “Diagnosis and management of rheumatoid arthritis.,” Am. Fam. Phys., 2005, 72, 1037-47.
Parada-Turska et al. “Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro,” Eur. J. Pharm., 2006, 535, 95-7.
Svetlov, S. I. et al . , EDG receptors and hepatic pathophysiology of LPA and SIP : EDG-ology of liver injury , Biochim . Biophys . Acta . , May 23, 2002, 1582 (1-3) : 251-6. , ISSN : 0006-3002.
International Search Report for PCT/JP03/06679 dated Jul. 29, 2003.

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