Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2001-02-20
2003-04-15
Weddington, Kevin E. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S531000, C514S532000
Reexamination Certificate
active
06548543
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a pharmaceutical composition containing a cyclopentenone ester as an active ingredient.
BACKGROUND ART
Wide variety of drugs including alkylating agents, antimetabolites, carcinostatics such as vegetable alkaloids, antibiotics, immunoenhancers and immnoregulators are conventionally used for clinical therapies. However, pharmacotherapy using such drugs has not completed yet.
Among these, naturally occurring prostaglandins having &agr;,&bgr;-unsaturated carbonyls in their five-membered rings, i.e., prostaglandins A and J, were reported to suppress DNA synthesis, suggesting their possible use as highly safe carcinostatics. Various derivatives thereof were synthesized (see JP-A 62-96438).
OBJECTS OF INVENTION
The main object of the present invention is to develop a cyclopentenone derivative having various physiological activities and to provide a pharmaceutical composition containing the compound as an active ingredient.
These and other objects as well as advantages of the present invention will be explained below in detail with reference to the attached drawings.
REFERENCES:
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patent: WO 98/13328 (1998-04-01), None
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Santoro, “Antiviral activity of cyclopentenone prostanoids”,Elsevier Science LTD.,(1997), vol. 5, No. 7, pp. 276-281.
Ikai Katsushige
Kato Ikunoshin
Kobayashi Eiji
Koyama Nobuto
Nishiyama Eiji
Browdy and Neimark , P.L.L.C.
Takara Shuzo Co. Ltd.
Weddington Kevin E.
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