Remedies for liver diseases

Details Remedies for liver diseases Remedies for liver diseases

1998-07-20

1999-10-26

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

A61K 3166

Patent

active

059729147

ABSTRACT:
The present invention discloses a method for the treatment of liver diseases, comprising administering an effective amount of an aminoalcohol of the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a phosphono group, R.sup.2 represents a hydrogen atom or a group --(CH.sub.2).sub.n --OR.sup.1, and n represents an integer between 2 and 5 inclusive. The present invention also relates to the use of the compound in the manufacture of a remedy for the treatment of liver diseases. This compound exhibits hepatocyte proliferation activity and liver disorder restoring effect, and thus is useful for the treatment of acute hepatitis, chronic hepatitis, hepatic cirrhosis, etc.

REFERENCES:
Hajime Sasaki et al, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 7320-7325, "Ethanolamine Modulates the Rate of Rat Hepatocyte Proliferation In Vitro and in Vivo", Jul. 1997.
Hajime Sasaki, et al., In Vitro Cell Dev. Biol.-Animal, vol. 34, pp. 68-73, "Stimulation of Rat Hepatocyte Proliferation In Vitro and In Vivo by Factors Derived from the Bovine Small Intestinal Mucosa", Jan. 1998.

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