Remedial agent for anxiety neurosis or depression and...

Details Remedial agent for anxiety neurosis or depression and... Remedial agent for anxiety neurosis or depression and...

2005-09-27

2005-09-27

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252180, C514S253010, C514S253060, C514S253120, C544S295000, C544S357000, C544S360000, C544S363000, C544S364000

Reexamination Certificate

active

06949552

ABSTRACT:
There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MC4receptor antagonist as an effective ingredient; and a piperazine derivative represented by Formula [1]:[wherein Ar1is a phenyl group, a substituted phenyl group, a naphthyl group or a substituted naphthyl group; Ar2is a naphthyl group, a substituted naphthyl group, a quinolyl group, a group represented by the formula:(wherein R4is a hydrogen atom or a halogen atom; and X—Y is CH—NH, CH—O, CH—S or N—O) or a group represented by the formula:(wherein R5is a hydrogen atom, a hydroxyl group or a C1-10alkoxy group); R1is a hydrogen atom, a C1-10alkyl group, a C3-8cycloalkyl group, a C3-10alkenyl group, a phenyl group, a 1-cyanoethyl group, a pyrimidin-2-yl group or an amidyl group; R2and R3are the same or different, and are each a hydrogen atom or a C1-10alkyl group; A-B is N—CH2, CH—CH2, C(OH)—CH2or C═CH; T1is a single bond, —N(R6)— (wherein R6is a hydrogen atom or a C1-10alkyl group), —O—, —CH═CH— or —C(═O)—; n is an integer of from 1 to 10 and when T1is a single bond, —CH═CH— or —C(═O)—, n is an integer of from 2 to 10 when T1is —N(R6)— or —O—], or a pharmaceutically acceptable salt thereof.

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