Relief from memory dysfunction with .alpha.-alkyl-4-amino-3-quin

Details Relief from memory dysfunction with .alpha.-alkyl-4-amino-3-quin Relief from memory dysfunction with .alpha.-alkyl-4-amino-3-quin

1988-11-14

1989-06-20

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3147

Patent

active

048409723

ABSTRACT:
There are described compounds of the formula ##STR1## where X is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl; R is ##STR2## R.sub.4 being loweralkyl; R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; R.sub.2 is hydrogen, loweralkyl or arylloweralkyl; and R.sub.3 is loweralkyl, with the proviso that when R is acetyl, R.sub.3 is methyl and X is hydrogen, R.sub.1 and R.sub.2 are not both hydrogen, or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory and for treating Alzheimer's disease.

REFERENCES:
patent: 2785165 (1957-03-01), Schock et al.
patent: 4180670 (1979-12-01), Edington et al.
patent: 4631286 (1986-12-01), Shutske et al.
patent: 4695573 (1987-09-01), Shutske et al.

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