Reliable noninvasive measurement of blood gases

Surgery – Truss – Pad

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128664, 128665, 128666, A61B 500

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active

053558804

ABSTRACT:
Methods and apparatus for, preferably, determining noninvasively and in vivo at least two of the five blood gas parameters (i.e., pH, PCO.sub.2, [HCO.sub.3.sup.- ], PO.sub.2, and O.sub.2 sat.) in a human. The non-invasive method includes the steps of: generating light at three or more different wavelengths in the range of 500 nm to 2500 nm; irradiating blood containing tissue; measuring the intensities of the wavelengths emerging from the blood containing tissue to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of at least two of pH, [HCO.sub.3.sup.- ], PCO.sub.2 and a measure of oxygen concentration. The determined values are within the physiological ranges observed in blood containing tissue. The method also includes the steps of providing calibration samples, determining if the spectral intensities v. wavelengths from the tissue represents an outlier, and determining if any of the calibration samples represents an outlier. The determination of the unknown values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. Preferably, there is a separate calibration for each blood gas parameter being determined. The method can be utilized in a pulse mode and can also be used invasively. The apparatus includes a tissue positioning device, a source, at least one detector, electronics, a microprocessor, memory, and apparatus for indicating the determined values.

REFERENCES:
patent: 4041932 (1977-08-01), Fostick
patent: 4114604 (1978-09-01), Shaw et al.
patent: 4201222 (1980-05-01), Hasse
patent: 4274418 (1981-06-01), Vesterager et al.
patent: 4324256 (1982-04-01), Vesterager et al.
patent: 4509522 (1985-04-01), Manuccia
patent: 4682985 (1987-07-01), Costello
patent: 4685465 (1987-08-01), Klitgaard et al.
patent: 4694834 (1987-09-01), Meyeroff et al.
patent: 4834532 (1989-05-01), Yount
patent: 4854321 (1989-08-01), Boiorski
patent: 4930506 (1990-06-01), Ullrich
patent: 4975581 (1990-12-01), Robinson et al.
patent: 4989606 (1991-02-01), Gehrich et al.
patent: 5103829 (1992-04-01), Suzuki et al.
Naes, T., et al., "Comparison of Linear Statistical methods for Calibration of NIR Instruments", Appl. Statist. (1986), 35, No. 2, pp. 195-206.
Drumm, G. W., "An Optical Scattering Technique for the Detection of pH-Induced Volume Changes of Erythrocytes in Whole Blood", A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Engineering, University of Washington, 1988.

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