Releasable polymeric conjugates based on aliphatic...

Details Releasable polymeric conjugates based on aliphatic... Releasable polymeric conjugates based on aliphatic...

2006-08-08

2006-08-08

Witz, Jean C. (Department: 1651)

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

C424S181100, C424S193100, C424S194100, C514S668000, C514S715000, C514S716000

Reexamination Certificate

active

07087229

ABSTRACT:
Activated polymeric bicine derivatives such as,as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.

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Greenwald et al. “A New Apiphatic Amino Prodrug System for the Delivery of Small Molecules and Proteins Utilizing Novel PEG Derivatives” J. Med. Chem. (2004) 47: 726-734.
Pasut et al. “Protein, peptide and non-peptide drug PEGylation for therapeutic application” Expert Opinion Ther. Patents (2004) 14(6): 859-894.
J. William Suggs, et al., Facile Hydrolysis and Formation of Amide Bonds by N-Hydroxyethylation of . . . , Tetrahedron Letters, vol. 38, No. 13, pp. 2227-2230, 1997.

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