Releasable polymeric conjugates based on aliphatic...

Details Releasable polymeric conjugates based on aliphatic... Releasable polymeric conjugates based on aliphatic...

2006-10-17

2006-10-17

Witz, Jean C. (Department: 1651)

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

C424S181100, C424S193100, C424S194100, C514S668000, C514S715000, C514S716000

Reexamination Certificate

active

07122189

ABSTRACT:
Activated polymeric bicine derivatives such asas well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.

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patent: 06240091 (1994-08-01), None
Greenwald et al. “A New Apiphatic Amino Prodrug System for the Delivery of Small Molecules and Proteins Utilizing Novel PEG Derivatives” J. Med. Chem. (2004) 47: 726-734.
Pasut et al. “Protein, peptide and non-peptide drug PEGylation for therapeutic application” Expert. Opin. Ther. Patents (2004) 14(6): 859-894.
Caplus Database, accession No. 1995:235122, abstract and structures for JP 06240091, printed on Feb. 3, 2006 from STN.
Dewent Database, accession No. 1994-313850, abstract for JP 06240091, printed on Feb. 3, 2006 from WEST.
Suggs, J. William, et. al., Facile Hydrolysis and Formation of Amine Bonds by N-Hydroxyethylation of Alpha-Amino Acids, Tetrahedron Letters. vol. 38, No. 13. pp. 2227-2230, 1997.

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