Releasable linkage and compositions containing same

Details Releasable linkage and compositions containing same Releasable linkage and compositions containing same

2007-07-03

2007-07-03

Riley, Jezia (Department: 1637)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S085100, C205S254000, C514S001000, C530S336000, C536S084000

Reexamination Certificate

active

10723473

ABSTRACT:
A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.

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