Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-08-23
2005-08-23
Falk, Anne-Marie (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C424S093600, C435S372000, C435S383000
Reexamination Certificate
active
06933150
ABSTRACT:
The present invention includes methods of performing ex vivo expansion of gene-modified hematopoietic stem cells which are useful for many applications involving bone marrow transplantation and ex vivo gene therapy. The present invention further includes the gene-modified hematopoietic stem cells that are used and produced by such methods. Such gene-modified hematopoietic stem cells can also contain a second heterologous gene. In addition, the present invention also includes methods of engrafting the gene-modified hematopoietic stem cells of the present invention into animals, including for ex vivo gene therapy and for reconstitution of hematopoietic cells in ablated mammals. The present invention also provides a method of isolating stem cells.
REFERENCES:
patent: 5837536 (1998-11-01), McDonagh et al.
patent: 6313277 (2001-11-01), Abruzzo et al.
patent: 93/24613 (1993-12-01), None
patent: 97/16535 (1997-05-01), None
patent: 98/12304 (1998-03-01), None
patent: WO 99/40110 (1999-08-01), None
patent: 99/61589 (1999-12-01), None
Hanazono et al.; Gene Transfer into Nonhuman Primate Hematopoietic Stem Cells: Implications for Gene Therapy 2001 Stem Cells 19: 12-22.
Bunting et al., Transduction of murine bone marrow cells with and MDR1 vector enables ex vivo stem cell expansion but these expanded grafts cause a myeloproliferative syndrome in transplanted mice, 1998, BLOOD, vol. 92, pp 2269-2279.
U.S. Appl. No. 60/086,988, filed May 28, 1998.
Allen et al., Cancer Res., 59:4237-41, 1999.
Allikmets et al., Hum. Mol. Genet., 5: 1649-55, 1996.
Bhatia et al., Nat Med.,, 4: 1038-45, 1998.
Bhatia et al., J Exp. Med., 186: 619-624, 1997.
Brangi et al., Cancer Research, 59:5938-5946, 1999.
Bunting et al., Blood, 92(7): 2269-79, 1998.
Chaudhary and Roninson, Cell, 66: 85-94, 1991.
Doyle et al., Proc. Natl. Acad. Sci. USA, 95: 15665-15670, 1998.
Galipeau et al., Human Gene Therapy., 8: 1773-83, 1997.
Giles et al., Cancer, 86: 805-813, 1999.
Glimm and Eaves, Blood, 94: 2161-68, 1999.
Goodell et al., J Exp Med., 183: 1797-1806, 1996.
Goodell et al., Nat. Med., 3: 1337-45, 1997.
Gruol and Bourgeois, Biochem. Cell. Biol., 72: 561-71, 1994.
Gussoni et al, Nature, 401: 390-4, 1999.
Hanania et al., Cancer Gene Therapy, 1(1): 21-25, 1994.
Hanania et al., Gene Ther., 2: 279-84, 1995.
Hrycyna et al., Biochemistry, 37: 13660-73, 1998.
Jackson et al., PNAS USA, 96: 14482-86, 1999.
Johnstone et al., Blood, 93: 1075-85, 1999.
Leith et al., Blood, 94: 1086-99, 1999.
Malieparard et al., Cancer Res., 59: 4559-63, 1999.
Michieli et al., Br. J. Haematol, 104: 328-335, 1999.
Miyake et al., Cancer Res., 59: 8-13, 1999.
Nakayama et al., Blood, 92: 4296-4307, 1998.
Osawa et al., Science, 273: 242-45, 1996.
Persons et al., Blood, 90(5):1777-1786, 1997.
Podda et al., PNAS USA, 89:9676-80, 1992.
Robinson et al., Biochemistry, 30: 11169-78, 1997.
Ross et al., Blood, 96(1):365-368, 2000.
Schinkel et al., PNAS USA, 94: 4028-33, 1997.
Shimizu et al., Blood, 91: 3688-92, 1998.
Smyth et al., PNAS USA, 95: 7024-29, 1998.
Sorrentino et al., Science, 257: 99-103, 1992.
Sorrentino et al., Blood, 86: 491-501, 1995.
Spencer et al., Blood, 87: 2579-87, 1996.
Tisdale et al., Blood, 92: 1131-41, 1998.
Traycoff et al., Exp. Hemotol., 26:53-62, 1998.
Zandstra et al., Proc. Natl. Acad. Sci. USA, 94:4698-4703, 1997.
Zanjani et al., Exp. Hematol., 26: 353-60, 1998.
Ziegler et al., Science, 285: 1553-8, 1999.
Bunting Kevin
Nakauchi Hiromitsu
Schuetz John
Sorrentino Brian
Falk Anne-Marie
Licata & Tyrrell P.C.
St. Jude Children's Research Hospital
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