Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Particulate matter
Patent
1989-06-26
1992-04-14
Lovering, Richard D.
Stock material or miscellaneous articles
Coated or structually defined flake, particle, cell, strand,...
Particulate matter
264 43, 264 432, 264 433, 264427, 424450, 436829, A61K 9127, B01J 1302, B01J 1316
Patent
active
051047365
ABSTRACT:
Disclosed are paucilamellar lipid vesicles reinforced with polyacrylamide, and methods of producing the same. The vesicles include about 2-10 lipid bilayers in the form of substantially spherical shells separated by a plurality of aqueous layers. Each of the bilayers have a layer of polyacrylamide lining its innermost side. The bilayers and the aqueous layers surround a large, substantially amorphous central cavity containing a water-immiscible oily phase or a polyacrylamide core. The method of the invention includes forming a lipophilic phase containing a surfactant and a lipid-soluble material to be encapsulated or to be incorporated into the lipid structure of the vesicle, forming an aqueous phase containing polyacrylamide; shear mixing the lipophilic phase and the aqueous phase, thereby forming a plurality of paucilamellar lipid vesicles containing acrylamide in their aqueous regions; separating the vesicles from any unincorporated vesicle constituents; and polymerizing the acrylamide in the aqueous layers of the vesicles. A method of encapsulating a water-soluble material is also disclosed.
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Lovering Richard D.
Micro-Pak, Inc.
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