Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1996-07-31
1998-04-07
Buiz, Michael Powell
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 27, 600309, A61M 2500
Patent
active
057358320
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The invention relates to a microdialysis probe. A dialysis probe of this kind is described in SE-C-434 214.
BACKGROUND OF THE INVENTION
Microdialysis is a method of examination in which a probe is inserted into tissue in vivo, such that one side of a semi-permeable membrane is in contact with tissue and body fluid, while the other side is flushed or rinsed with a dialysis liquid which takes-up substances through the membrane, which substances can then be analyzed in the liquid that has flown past. This method has made large advances in recent years and the number of research publications relating to microdialysis have multiplied in frequency a thousand-fold in ten years.
The use in clinical and polyclinical activities for diagnostic purposes on human beings, however, has been held back, primarily because dialysis probes are relatively fragile by nature, which makes it difficult to insert and remove the probe. At least part of the probe must have a surface which consists of a thin, semi-permeable membrane which is easily broken, particularly when removing the probe. The problem is not as large during insertion, since during insertion an external tube is normally used which is removed after insertion while leaving the probe in place. This outer tube may have the form of a plastic tube which can be withdrawn and slit flush with the skin as the tube is gradually withdrawn, with the probe left in position.
However, when the probe is inserted into tissue of a living person, the probe must be able to retain its shape despite the stresses and strains that can be expected when the person moves. A still greater problem occurs when the probe is to be withdrawn after use. In the case of the known probe, withdrawal may result in part of it being left in the body.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the invention to provide a microdialysis probe which is suitable for general human use when taking samples for a diagnostic purpose as a routine method. In particular the risk of material being left behind when the probe is withdrawn must be overcome.
These and other objects are achieved and the aforementioned risks avoided to the highest degree in accordance with the invention by modifying a microdialysis probe of the kind defined in the introduction in the manner defined in the characterizing clause of the following Claim 1. Preferred embodiments are defined in the depending Claims.
Because the distal end of the probe is fixedly joined to the center tube, safe withdrawal of this end is guaranteed. Furthermore, it is also ensured that no part of the mantle tube will remain, since even if the tube should be broken, the worst that can happen is only a certain degree of movement towards the distal end, which has a larger diameter and which when withdrawn from the insertion hole will entrain any pieces that may have broken off from the mantle tube.
BRIEF DESCRIPTION OF THE DRAWINGS
The invention will now be described in more detail with reference to an illustrative but not limiting embodiment thereof. FIG. 1 is a schematic side view of a microdialysis probe. FIG. 2 illustrates a center tube. FIG. 3 illustrates in larger scale and in section a distal end of a microdialysis probe. FIG. 4 shows a proximal end of a microdialysis probe also in larger scale and in section.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The probe 1 shown in FIG. 1 has at its distal end an enlarged fitting in the form of a first tube 2 from which there protrudes a mantle tube 3, which is somewhat narrower. The mantle tube 3 extends to a second tube 4 and penetrates the second tube. In turn, the second tube 4 extends to a distal end-piece 5, from which two external connecting pipes 6 and 7 extend.
In the invention, it is not actually the at least partially very thin mantle tube 3 which is the supporting structure. Rather the mantle tube encases a centre tube 8 which extends between the end-piece 5 and the fitting 2 and which is fastened to the fitting 2 so that the mantle tube 3 is essentially clamped be
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patent: 5156844 (1992-10-01), Aebischer et al.
patent: 5191900 (1993-03-01), Mishra
patent: 5441481 (1995-08-01), Mishra et al.
patent: 5607390 (1997-03-01), Patsalos et al.
Blyveis Deborah
Buiz Michael Powell
CMA/Microdialysis Holding AB
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