Regulatory T cells; methods

Details Regulatory T cells; methods Regulatory T cells; methods

2006-10-17

2006-10-17

Chan, Christina (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

C435S325000, C435S383000, C435S377000, C435S405000

Reexamination Certificate

active

07122340

ABSTRACT:
Methods for increasing yields of regulatory T cells, useful, e.g., in transplantation contexts. Use of antigen presenting cells and anti-CD28 are also described.

REFERENCES:
patent: 5858358 (1999-01-01), June et al.
patent: 6670146 (2003-12-01), Barrat et al.
patent: WO 91/04030 (1991-04-01), None
M. Heloisa Blotta, et al.,J Immunol, 158(12):5589-5595, Jun. 15, 1997. “Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes”.
Frank Bridoux, et al.,J Exp Med, 185(10):1769-1775, May 19, 1997. “Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines”.
Jan Buer, et al.,J Exp Med, 187(2):177-183, Jan. 19, 1998. “Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo”.
Nitya G. Chakraborty, et al.,J Immunol, 162(9):5576-5583, May 1, 1999. “Emergence of regulatory CD4+ T cell response to repetitive stimulation with antigen-presenting cells in vitro: implications in designing antigen-presenting cell-based tumor vaccines”.
Rongbing Chen, et al.,J Immunol, 164(2):825-832, Jan. 15, 2000. Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter.
Daniele D'Ambrosio, et al.,J Clin Invest, 101(1):252-262, Jan. 1, 1998. “Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p. 40 gene”.
Karolien De Bosscher, et al.,Proc Natl Acad Sci U S A, 94(25):13504-13509, Dec. 9, 1997. “Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation”.
Herve Groux, et al.,Nature, 389(6652):737-742, Oct. 16, 1997. “A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis”.
Giandomenica Iezzi, et al.,Eur J Immunol, 29(12):4092-4101, Dec. 1999. “The interplay between the duration of TCR and cytokine signaling determines T cell polarization”.
Michael Karin,Cell, 93(4):487-490, May 15, 1998. “New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?”.
Ui Yen Khoo, et al.,J Immunol, 158(8):3626-3634, Apr. 15, 1997. CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens.
Frank Mattner, et al.,Eur J Immunol, 30(2):498-508, Feb. 2000. “Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)”.
Carla Miller, et al.,J Exp Med, 190(1):53-64, Jul. 5, 1999. “Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo”.
Anne O'Garra,Immunity, 8(3):275-283, Mar. 1998. “Cytokines induce the development of functionally heterogeneous T helper cell subsets”.
Lorenzo Piemonti, et al.,J Immunol, 164(9):4443-4451, May 1, 2000. “Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells”.
Francisco Ramirez, et al.,J Immunol, 156(7):2406-2412, Apr. 1, 1996. “Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro”.
David F. Richards, et al.,Eur J Immunol, 30(8):2344-2354, Aug. 2000. “Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production”.
Chao-Zhong Song, et al.,Proc Natl Acad Sci U S A, 96(21):11776-11781, Oct. 12, 1999. “Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3”.
Pedro L. Vieira, et al.,J Immunol, 161(10):5245-5251, Nov. 15, 1998. “Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential”.
Jeroen Visser, et al.,Blood, 91(11):4255-4264, Jun. 1, 1998. “Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro”.
Thomas Wilckens and Roel De Rijk,Immunol Today, 18(9):418-424, Sep. 1997. “Glucocorticoids and immune function: unknown dimensions and new frontiers”.
Junn Yanagisawa, et al.,Science, 283(5406):1317-1321, Feb. 26, 1999. “Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators”.

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