Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Patent
1990-09-24
1993-08-31
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
43525421, 435 691, 4353201, 536 241, 935 6, 935 37, 935 69, C12N 119, C12N 1581, C12N 1511
Patent
active
052408388
ABSTRACT:
The structural genes and their regulatory DNA sequences of an alcohol oxidase (MOX) and a dihydroxyacetone synthase (DHAS) of Hansenula polymorpha have been isolated and the nucleotide sequences determined. The invention relates to the use of the MOX gene, as well as the use of the regulatory DNA sequences of MOX and/or DAS in combination with the MOX gene, optionally after modification thereof, or other oxidase genes, or other genes, to produce engineered microorganisms, in particular yeasts. Said engineered microorganisms can produce oxidases or other enzymes in yields that allow industrial application on a large scale. Moreover, said engineered microorganisms can produce oxidases having improved properties with respect to their application in oxidation reactions and/or in bleaching and detergent products.
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Hollenberg Cornelis P.
Janowicz Zbigniew A.
Ledeboer Adrianus M.
Maat Jan
Verrips Cornelis T.
Internationale Otrool Maatschappij "Octropa" B.V.
Mosher Mary E.
Schwartz Richard A.
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