Regulatory protein for Nox enzymes

Details Regulatory protein for Nox enzymes Regulatory protein for Nox enzymes

2007-07-17

2007-07-17

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S189000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

11227975

ABSTRACT:
The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these nucleotides, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these nucleotides and proteins, and methods to determine the activity of drugs to affect the biological activity of the regulatory proteins of the present invention.

REFERENCES:
patent: 6620603 (2003-09-01), Lambeth et al.
patent: WO 00/28031 (2000-05-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 01/87957 (2001-11-01), None
patent: WO 02/081703 (2002-10-01), None
Burdon, “Superoxide and hydrogen peroxide in relation to mammalian cell proliferation,”Free Radical Biol. Med., 18(4):775-794 (1995).
Cheng, G. et al.,Gene, 269:131:140 (May 16, 2001).
Cheng, Guangjie et al.,Journal of Biological Chemistry,279(6):4737-4742 (Feb. 6, 2004).
Cheng, Guangjie et al.,Journal of Biological Chemistry, 279(33):34250-34255 (Aug. 13, 2004).
Church, S.L., et al., “Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells,”Proc. Natl. Acad. Sci. USA90:3113-3117 (1993).
Dahan et al., “Mapping of Functional Domains in the p22phoxSubunit of Flavocytochrome b559Participating in the Assembly of NADPH Oxidase Complex by Peptide Walking,”J. Biol. Chem., vol. 277, No. 10, pp. 8421-8432 (2002).
Edens, W., et al., “Tyrosine cross-linking of extracellular matrix is catalized by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox, ”J. Cell Biol. 154(4):879-91 (Aug. 20, 2001).
Fernandez-Pol, J.A., et al., “Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells,”Can. Res. 42:609-617 (1982).
Fukui, T., et al., “p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats,”Circ. Res. 80(1):45-51 (1997).
Geiszt, Miklos et al.,Journal of Biological Chemistry, 278(22):20006-20012 (May 30, 2003).
Griendling, K.K., et al., “Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.”Circ. Res. 74(6):1141-1148 (1994).
Irani, K., et al., “Mitogenic signaling mediated by oxidants in ras-transfromed fibroblasts,”Science275(5306):1649-1652 (1997).
Lambeth, J.D., et al., “Novel homologs of gp91phox,” Trends Biochem. Sci., 10:459-461 (Oct. 25, 2000).
Li, Y., et al., “Validation of lucigenin (Bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic cellular systems,”J. Biol. Chem. 273(4):2015-2023 (1998).
Maly et al., “Restitution of Superoxide Generation in Autosomal Cytochrome-negative Chronic Granulomatous Disease (A22° CGD)-derived B Lymphocyte Cell Lines by Transfection with p22phoxcDNA,”J. Exp. Med., 178:2047-2053 (1993).
Matsurbara, T., et al., “Increased superoxide anion release from human endothelial cells in response to cytokines,”J. Immun. 137(10):3295-3298 (1986).
Meier, B., et al., “Human fibroblasts released reactive oxygen species in response to interleukin-1 or tumor necrosis factor-α,”Biochem. j. 263(2):539-545 (1989).
Pagano, P.J., et al., “Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II,”Proc. Natl. Acad. Sci. USA94(26):14483-14488 (1997).
Schmidt, K.N., et al., “The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB,”Chem. &Biol., 2(1):13-22 (1995).
Schreck, R., et al., “Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1,”EMBO J., 10(8):2247-2258 (1991).
Sumimoto et al., “Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase,”Proc. Natl, Acad. Sci. USA, vol. 91, pp. 5345-5349 (1994).
Sundaresan, M., et al., “Requirement for generation of H2O2for platelet-derived growth factor signal transduction,”Science270:296-299 (1995).
Szatrowski, T.P., et al., “Production of large amounts of hydrogen peroxide by human tumor cells,”Canc. Res. 51(3):794-798 (1991).
Takeya, Ryu et al.,Journal of Biological Chemistry, 278(27):25234-25246 (Jul. 4, 2003).
Uhlinger, D.J., “Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system for hum neutrophils,” 266(31):20990-20997 (1991).
Ushio-Fukai M., et al., “p22phoxis a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells,”J. Biol. Chem., 271(38):23317-23321 (1996).
Yan, T., et al., Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts,Canc. Res. 56:2864-2871 (1996).
Yu, L., et al., “Biosynthesis of the phagocyte NADPH oxidase cytochrome b558,”J. Biol. Chem., 272(43):27288-27294 (1994).
Paulus et al., “NAD(P)H oxidase: a perpetrator of cardiovascular damage,” www.servier.com/pro/cardiologie/pdfs/pau29ang.asp, Mar. 24, 2004.
Genbank Accession No. AAS89434, Apr. 22, 2004.
Genbank Accession No. AAG24891, Dec. 6, 2000.

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