Regulatory nucleic acid for the ABC1 gene, molecules...

Details Regulatory nucleic acid for the ABC1 gene, molecules... Regulatory nucleic acid for the ABC1 gene, molecules...

2008-05-27

2008-05-27

Sullivan, Daniel M (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C536S024100, C435S320100, C435S252300

Reexamination Certificate

active

07378274

ABSTRACT:
The present invention concerns a nucleic acid which is capable of regulating the transcription of the ABC1 gene, which is a causal gene for pathologies linked to a dysfunctioning of cholesterol metabolism, inducing diseases such as atherosclerosis. The invention also relates to nucleotide constructs comprising a polynucleotide which encodes a polypeptide or a nucleic acid of interest, placed under the control a regulatory nucleic acid for the ABC1 gene. The invention also relates to recombinant vectors, transformed host cells and nonhuman transgenic mammals comprising a nucleic acid which regulates the transcription of the ABC1 gene or an abovementioned nucleotide construct, as well as methods for screening molecules or substances which are capable of modifying the activity of the regulatory nucleic acid for the ABC1 gene.

REFERENCES:
patent: 5872237 (1999-02-01), Feder et al.
patent: 6617122 (2003-09-01), Hayden et al.
patent: 6773893 (2004-08-01), Tall
patent: WO 00/78971 (2000-12-01), None
patent: WO 01/15676 (2001-03-01), None
Langmann, et al. Biochemical and Biophysical Research Communications 257: 29-33, Feb. 9, 1999.
Pullinger, et al. Biochemical and Biophysical Research Communications. May 10, 2000. vol. 271, pp. 451-455.
Santamarina, et al. PNAS USA. Jul. 5, 2000. vol. 97, No. 14, pp. 7987-7992.
NCBI Entrez Nucleotide Database entry AC012230.2 (Nov. 19, 1999), http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=645033, downloaded Jul. 25, 2007.
Osoegawa et al. (2001) Genome Res. 11:483-496.
Bodzioch, M., et al., “The Gene Encoding ATP-Binding Cassette Transporter 1 is Mutated in Tangier Disease,”Nature Genetics22:347-351 (1999).
Langmann, T., et al., “Molecular Cloning of the Human ATP-Binding Cassette Transporter 1 (hABC1): Evidence for Sterol-Dependent Regulation in Macrophages,”Biochemical and Biophysical Research Communications257:29-33 (1999).
Luciani, M.F., et al., “Cloning to Two Novel ABC Transporters Mapping on Human Chromosome 9,”Genomics21:150-159 (1994).
Marcil, M., et al., “Mutations in the ABC1 Gene in Familial HDL Deficiency with Defective Cholesterol Efflux,”The Lancet354:1341-1346 (1999).
Remaley, A.T., et al., “Human ATP-Binding Cassette Transporter 1 (ABC1): Genomic Organization and Identification of the Genetic Defect in the Original Tangier Disease Kindred,”Proc. Natl. Acad. Sci. USA96:12685-12690 (1999).
Rust, S., et al., “Assignment of Tangier Disease to Chromosome 9q31 By a Graphical Linkage Exclusion Strategy,”Nature Genetics20:96-98 (1998).
Rust, S., et al., “Tangier Disease is Caused by Mutations in the Gene Encoding ATP-Binding Cassette Transporter 1,”Nature Genetics22:352-355 (1999).
Database EM—HTG ′Online! EBI, Hinxton, U K; AC/ID AC012230, (Oct. 22, 1999) Birren B et al.: “Homo sapiensclone RP11-1M10” XP002192928 See nucleotides 1100-1680, 3660-390-. 120320-120490 and 151260-151510 abstract.

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