Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1988-10-11
1992-03-03
Martinell, James
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 701, 435 704, C07K 1506, C12P 2100
Patent
active
050934791
ABSTRACT:
An interleukin-1 preparation is obtained as a supernatant by cell culturing human peripheral mononuclear blood cells.
REFERENCES:
patent: 4613459 (1986-09-01), Cantor et al.
Mizel et al, "Purification to Apparent Homogeneity of Murine Interleukin 1", J. Immunol. 126: 834 (1981).
Togawa et al, "Characterization of Lymphocyte-Activating Factor (LAF) Produced by Human Mononuclear Cells: Biochemical Relationship of High and Low Molecular Weight Forms of LAF", J. Immunol. 122: 2112 (1979).
Lachman et al, "Purification of Human Interleukin 1", Chem. Abstr. 94: 137539t (1981) of J. Supramolec. Struct. 13: 457 (1980).
Lachman et al, "Partial Purification of Human Lymphocyte Activating Factor", Chem. Abstr. 93: 165824e (1980) of Prep. Biochem. 10: 387 (1980).
Mizel et al, "Characterization of Lymphocyte Activating Factor Obtained from the Murine Microphage Cell Line P388D1", Chem. Abstr. 93:93346a (1980), of Biochem. Charact. Lymphokines, Proc. Int. Lymphokine Workshop 2nd (1979) pp. 411-418.
Economou et al, "Purification, Physicochemical Characterization and a Biological Role of Lymphocyte Activating Factor (LAF)", Chem. Abstr. 93: 93347b (1980) of Biochem. Charact. Lymphokines, Proc. Int. Lymphokine Workshop, 2nd (1979) pp. 419-421.
Murphy et al, "Endogenous Pyrogens made by Rabbit Peritoneal Exudate Cells are Identical with Lymphocyte-Activating Factors made by Rabbit Alveolar Macrophages", J. Immunol. 124: 2498 (1980).
Simon et al, "The Role of Subcellular Factors in Pulmonary Immune Function: Physicochemical Characterization of Two Distinct Species of Lymphocyte-Activating Factor Produced by Rabbit Alveolar Macrophages", J. Immunol. 126: 1534 (1981).
Fabricius Hans-Ake
Kottgen Eckart
Martinell James
Shanksville Corp. N.V.
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