Regulatory genetic DNA that regulates the Class II transactivato

Details Regulatory genetic DNA that regulates the Class II transactivato Regulatory genetic DNA that regulates the Class II transactivato

1997-03-13

2000-02-08

McKelvey, Terry

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435243, 4353201, 435325, 435410, 536 231, 536 241, C12N 508, C12N 100, C12N 510, C12N 1511

Patent

active

060227419

ABSTRACT:
Novel DNAs that regulate expression of the Class II Transactivator (CIITA) gene are disclosed. Recombinant DNA comprising CIITA regulatory elements operably associated with a heterologous DNA are also disclosed. Additionally, assay systems for identifying compounds that regulate expression of the class II major histocompatibility (MHC) antigens are also disclosed.

REFERENCES:
Chin et al.; "Molecular Analysis of G1B and G3A IFN.gamma. Mutants Reveals that Defects in CIITA or RFX Result in Defective Class II MHC and li Gene Induction"; Immunity, 1:687-697 (1994).
Devajyothi et al.; "Inhibition of Interferon-.gamma.-induced Major Histocompatibility Complex Class II Gene Transcription by Interferon-.beta. and Type .beta.1 Transforming Growth Factor in Human Astrocytoma Cells"; J. of Biol. Chem., 268:18794-18800 (1993).
Improta et al.; "Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat 91 protein"; Proc. Natl. Acad. Sci. USA, 91:4776-4780 (1994).
Panek and Benveniste; "Class II MHC Gene Expression in Microglia-Regulation by the Cytokines IFN-.gamma., TNF-.alpha., and TGF-.beta."; J. of Immunology, pp. 2846-2854; .COPYRGT. 1995 by The Amer. Assoc. of Immunologists 0022-1767/95.
Reimold et al.; "Transforming Growth Factor .beta..sub.1 Repression of the HLA-DR.alpha. Gene Is Mediated by Conserved Proximal Promoter Elements"; J. of Immunology, 151(8):4173-4182 (1993).
Riley et al.; "Activation of Class II MHC Genes Requires Both the X Box Region and the Class II Transactivator (CIITA)"; Immunity, 2:533-543 (1995).
Zhou and Glimcher; "Human MHC Class II Gene Transcription Directed by the Carboxyl Terminus of CIITA, One of the Defective Genes in Type II MHC Combined Immune Deficiency"; Immunity, 2:545-553 (1995).
A. Lennon et al.; "Isolation of a B-cell-specific promoter for the human class II transactivator"; Immunogenetics, 45:266-273 (1997).
Genebank, Accession No. U67329, published Mar. 29, 1997; A. Lennon et al.; "Isolation of a B-cell-specific promoter for the human class II transactivator", Immunogenetics, 45:266-273 (1997).
V. Steimle et al.; Complementation Cloning of an MHC Class II Transactivator Mutated in Hereditary MHC Class II Deficiency (or Bare Lymphocyte Syndrome), Cell, 75:135-146 (1993).

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