Regulatory constructs comprising intron 3 of prostate...

Details Regulatory constructs comprising intron 3 of prostate... Regulatory constructs comprising intron 3 of prostate...

2006-07-11

2006-07-11

Guzo, David (Department: 1636)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C424S093600, C435S320100, C435S069100, C536S023100, C536S023500, C536S024100

Reexamination Certificate

active

07074400

ABSTRACT:
The invention provides regulatory constructs comprising intron 3 of the prostate specific membrane antigen gene (PSMA). An isolated nucleic acid molecule encoding the partial sequence of intron 3 of PSMA, a vector and a recombinant expression cassette are disclosed. The invention also provides a method of directing expression of a coding sequence in a prostate cell, a bladder cell, a breast cell and a vascular endothelial cell using the said constructs. This invention further provides a method of treatment of cancer using the said constructs.

REFERENCES:
patent: 5538866 (1996-07-01), Israeli et al.
patent: 51725 96 (1996-09-01), None
patent: WO 98 33903 (1998-08-01), None
Orkin, et al. Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy, The National Institutes of Health, Dec. 7, 1995.
Verma, et al. Nature, Sep. 1997, vol. 389, pp. 239-242.
Anderson, French W. Nature, Apr. 1998, vol. 392, pp. 25-30.
Palù et al. J. Biotechnol, 1999, vol. 68, pp. 1-13.
Luo et al, Nature Biotechnology, 2000, vol. 18, pp. 33-37.
Check, Erica. Nature, Feb. 2003, vol. 421, p. 678.
“Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene”, O'Keefe et al., Biochemica et Biophysica Acta 1443, (1998), pp 113-127.
Genbank Accession No. AF007544.
“Detailed genetic mapping around a putative prostate-specific membrane antigen locus on guman chromosome 11p11.2”, Maraj et al., Cytogenetics and Cell Genetics, Vo. 81 (1998). pp. 3-9.
“Cloning and Characterization of the Prostate-Specific Membrane Antigen Promoter”, Good. D. et al., Journal of Cellular Biochemistry 74(3), pp. 395-405, Sep. 1999.
“Prostate-Specific Membrane Antigen”, W. R. Fair et al., Prostate, Wiley-Liss, New York, NY, US, vol. 32, No. 2, 1997, pp. 140-148, XP000870112. ISSN: 0270-4137.

Affiliated with

Also associated with

Rating

Regulatory constructs comprising intron 3 of prostate... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regulatory constructs comprising intron 3 of prostate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regulatory constructs comprising intron 3 of prostate... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3599582