Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-05-20
1998-12-08
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
514 12, 536 235, C07K 14435, C07K 1447, C12N 1512
Patent
active
058470760
ABSTRACT:
Regulators of the activation of the 20S proteasome for hydrolysis of peptide and protein substrates. Proteasome activating factors PA28 and PA700 are described and a carboxy-terminal fragment of a protein activator PA28 is described that is an effective inhibitor of the activation of the proteasome. The carboxy-terminal fragment binds to the proteasome and prevents the binding of PA28 and PA700 thereby preventing activation of the proteasome. Methods of treatment for muscle wasting are described wherein compositions of the present invention are administered to prevent unwanted protein degradation. Conversely, compositions of the present invention may be used to activate protein breakdown in situations where unwanted proteins accumulate in, for example, aging and Alzheimer's Disease.
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Chu-Ping Ma
DeMartino George N.
Slaughter Clive A.
Willy Patricia J.
Board of Regents , The University of Texas System
Prouty Rebecca
Wax Robert A.
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