Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2011-08-16
2011-08-16
Lewis, Patrick (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C514S080000, C514S085000
Reexamination Certificate
active
07998946
ABSTRACT:
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
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Beachy Philip A.
Chen James K.
Taipale Anssi Jussi Nikolai
Johns Hopkins University School of Medicine
Lewis Patrick
Ropes & Gray LLP
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