Regulators of NFAT and/or store-operated calcium entry

Details Regulators of NFAT and/or store-operated calcium entry Regulators of NFAT and/or store-operated calcium entry

2009-10-08

2011-11-01

Vivlemore, Tracy (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S024500

Reexamination Certificate

active

08048864

ABSTRACT:
Embodiments of the inventions relates to modulating NFAT activity, modulating store-operated Ca2+entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of proteins involved in the calcineurin/NFAT axis.

REFERENCES:
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Ishikawa, J. et al., “A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained CA2+ Influx and IL-2 Production in T Lymphocytes”, J. Immunol., 170, pp. 4441-4449, 2003.
Ohga, K. et al., “Characterization of YM-58483/BTP2, A Novel Store-Operated CA2+ Entry Blocker, on T Cell-Mediated Immune Responses in Vivo”, International Immunopharamcology 8, pp. 1787-1792, 2008.
Picard, C. et al., “STIM1 Mutation Associated With a Syndrome of Immunodeficiency and Autoimmunity”, N. Engl. J. Med. 360(19), pp. 1971-1980, May 7, 2009.
Swanson, S. et al., “Cyclosporin-Mediated Inhibition of Bovine Calcineurin by Cyclophilins A and B”, Proc. Natl. Acad. Sci., vol. 89, pp. 3741-3745, May 1992.
Trevillyan, J. et al., “Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds”, The Journal of Biological Chemistry, vol. 276, No. 51, pp. 48118-48126, Dec. 21, 2001.
Wittmann, M. et al., “Ciritcal Involvement of IL-12 in IFN-gamma Induction by Calcineurin Antagonists in Activated Human Lymphocytes”, Journal of Leukocyte Biology, vol. 80, pp. 75-86, Jul. 2006.
Wulff, H. et al., “Design of a Potent and Selective Inhibitor of the Intermediate-Conductance CA2+-Activated K+ Channel, IKCA1: A Potential Immunosuppressant”, PNAS, vol. 97, No. 14, pp. 8151-8156, Jul. 5, 2000.

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