Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-04-24
1999-10-12
LeGuyader, John L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 500
Patent
active
059657065
ABSTRACT:
The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.
REFERENCES:
Henschel et al. EMBL/GenBank. Accession #P41737, Nov. 1995.
Katzav, S., et al., "Loss of the Amino-Terminal Helix-Loop-Helix Domain of the vav Proto-Oncogene Activates Its Transformating Potential," Molecular and Cellular Biology, 11(4):1912-1920 (1991).
Benezra, R., et al., "The Protein Id: A Negative Regulatory of Helix-Loop-Helix DNA Binding Proteins," Cell, 61:49-59 (1990) (GI 202344; GI 202343; GI 340190).
Database EMBL--EMEST7, Entry HS754326, Acc. No. WO7754, Apr. 27, 1996, Hillier, L. et al.: "yx88d12.sl Homo sapiens cDNA clone 268823 3'.", XP002069469.
Database EMBL--EMEST8, Entry HS800173, Acc. No. H26800, Jul. 15, 1995, Hillier, L. et al.: "y163c02.rl Homo sapiens cDNA clone 162914 5'.", XP002069470.
Database EMBL--EMEST4, Entry HS032282, Acc. No. N24032, Dec. 30, 1995, Hillier, L. et al.: "zb03d08.rl Soares fetal lung NbHL19W Homo sapiens cDNA clone 300975 5' similar to SW:NEUR.sub.-- FELCA p41737 Neuronal Protein. [1] ;." XP00206471.
Goli Surya K.
Hillman Jennifer L.
Streeter David G.
Incyte Pharmaceuticals Inc.
LeGuyader John L.
Wang Andrew
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