Regulation of type II collagen gene expression using...

Details Regulation of type II collagen gene expression using... Regulation of type II collagen gene expression using...

2007-07-19

2010-06-22

Ketter, James S (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S377000, C435S173800, C607S065000

Reissue Patent

active

RE041391

ABSTRACT:
Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate specific and selective fields optimized for type II collagen gene expression and exposing cartilage tissue to the specific and selective fields generated by specific and selective signals so as to regulate type II collagen gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.

REFERENCES:
patent: 4430999 (1984-02-01), Brighton et al.
patent: 4442846 (1984-04-01), Brighton et al.
patent: 4467808 (1984-08-01), Brighton et al.
patent: 4467809 (1984-08-01), Brighton et al.
patent: 4487834 (1984-12-01), Brighton
patent: 4506674 (1985-03-01), Brighton et al.
patent: 4509520 (1985-04-01), Dugot
patent: 4535775 (1985-08-01), Brighton et al.
patent: 4549547 (1985-10-01), Brighton et al.
patent: 4600010 (1986-07-01), Dugot
patent: 4683873 (1987-08-01), Cadossi et al.
patent: 4998532 (1991-03-01), Griffith
patent: 5014699 (1991-05-01), Pollack et al.
patent: 5038797 (1991-08-01), Batters
patent: 5269746 (1993-12-01), Jacobson
patent: 5273033 (1993-12-01), Hoffman
patent: 5338286 (1994-08-01), Abbott et al.
patent: 5374283 (1994-12-01), Flick
patent: 5743844 (1998-04-01), Tepper et al.
patent: 5968527 (1999-10-01), Litovitz
patent: 6083149 (2000-07-01), Wascher et al.
patent: 6132362 (2000-10-01), Tepper et al.
patent: 6186940 (2001-02-01), Kirschbaum
patent: 6261221 (2001-07-01), Tepper et al.
patent: 6292699 (2001-09-01), Simon et al.
patent: 6485963 (2002-11-01), Wolf et al.
patent: 6605089 (2003-08-01), Michelson
patent: 6747004 (2004-06-01), Tabibzadeh
patent: 6919205 (2005-07-01), Brighton
patent: 6955642 (2005-10-01), Simon
patent: 7022506 (2006-04-01), Brighton et al.
patent: 7130692 (2006-10-01), Brighton et al.
patent: 7158835 (2007-01-01), Brighton et al.
patent: 7167753 (2007-01-01), Brighton et al.
patent: 7215995 (2007-05-01), Brighton et al.
patent: 7374916 (2008-05-01), Brighton
patent: 7465546 (2008-12-01), Brighton
patent: 7465566 (2008-12-01), Brighton et al.
patent: 2002/0038137 (2002-03-01), Stein
patent: 2002/0052634 (2002-05-01), March
patent: 2003/0211084 (2003-11-01), Brighton et al.
patent: 2005/0049640 (2005-03-01), Gurtner et al.
patent: 2005/0203591 (2005-09-01), Brighton
patent: 2006/0190043 (2006-08-01), Brighton et al.
patent: 2006/0235473 (2006-10-01), Brighton
patent: 2007/0299472 (2007-12-01), Brighton
patent: 0 652 028 (1995-05-01), None
patent: 1 198 580 (2006-05-01), None
patent: 2147895 (2000-04-01), None
patent: WO 00/02585 (2000-01-01), None
patent: WO 01/62336 (2001-08-01), None
patent: WO 2005/070136 (2005-08-01), None
Heermeier. K., et al., Effects of extremely low frequency electromagnetic field (EMF) on collagen type 1 mRNA expression and extracellular matrix synthesis of human osteoblastic cells, Bioelectromagnetic, 1998, 19, 222-231.
Pezzetti, F., et al., “Effects of pulsed electromagnetic fields on human chondocytes; an in vitro study,” Calcif Tissue Int., 1999, 65, 396-401.
U.S. Appl. No. 10/257,126, filed Oct. 2002, Brighton.
U.S. Appl. No. 10/255,241, filed Sep. 2002, Brighton et al.
U.S. Appl. No. 10/461,188, filed Jun. 2003, Brighton.
U.S. Appl. No. 10/585,718, filed Jul. 2006, Brighton.
Aaron, R.K., et al., “The conservative treatment of osteonecrosis of the femoral head,”Clin. Orthop., 1989, 249, 209-218.
Aaron, R.K., et al., “Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields,”K. Bone Miner. Res., Nov. 2, 1989, 4, 227-233.
Ala-aho, R., et al. “Targeted inhibitition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo,” Oncogene, 2004-23, 5111-5123.
Bassett, C.A.L., “Low energy pulsing electromagnetic fields modify biomedical processes,”BioEssays, 1987, 6(1), 36-42.
Bassett, C.A.L., et al. “Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis,”Clin. Orthop., Sep. 1989, 246, 172-185.
Bassett, C.A.L., et al., “Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMSs), ”Crit. Rev. Biomed. Eng., 1989, 17(5), 451-529.
Bassett, C.A.L., et al., “Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses,”JAMA, Feb. 5, 1982, 247(5), 623-628.
Binder, A., et al., “Pulsed electromagnetic field therapy of persistent rotator cuff tendonitis,”Lancet, Mar. 31, 1984, 695-698.
Brighton, C.T., et al., “A multicenter study of the treatment of non-union with constant direct current,”J. Bone and Joint Surgery, Jan. 1981, 62-A(1), 2-13.
Brighton, C.T., et al., “Treatment of recalcitrant non-union with a capacitively coupled electrical field,”J. Bone and Joint Surgery, Apr. 1985, 67-A(4), 577-585.
Brighton, C.T., et al., “Treatment of castration-induced osteoporosis by a capacitively coupled electrical in rat vertebrae,”J. Bone and Joint Surgery, Feb. 1989, 71-A(2), 228-236.
Brighton, C.T., et al., “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes,”J. Orthop. Res., 1988, 6, 552-558.
Brighton, C.T., et al., “Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption,”J. Orthop. Res., 1988, 6, 676-684.
Brighton, C.T., et al., “Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields,”J. Orthop. Res., 1985, 3, 331-340.
Brighton, C.T., et al., “In vitrobone-cell response to a capacitively coupled electrical field,”Clin. Orthop. Related Res., Dec. 1992, 285, 255-262.
Brighton, C.T., et al., “Signal transduction in electrically stimulated bone cells,”J. Bone Joint Surg. Am., 2001, 83-A(10), 1514-1523.
Brighton, C.T., et al., “Prevention and treatment of sciatic denervation disuse osteoporosis in rat tibia with capacitively coupled electrical stimulation,”Bone, 1985, 6, 87-97.
Brighton, C.T., et al., “Treatment of nonunion of the tibia with a capacitively coupled electrical field,”J. of Trauma, 1984, 24(2), 153-155.
Brighton, C.T., et al., “Tibial nonunion treated with direct current, capacitive coupling, or bone graft,”Clin. of Orthop. and Related Res., 1995, 321, 223-234.
Carter, E.L., et al., “Field distributions in vertebral bodies of the rat during electrical stimulation: a parametric study,”IEEE Trans. on Biomed. Eng., Mar. 1989, 36(3), 333-345.
Goodman, R., et al., “Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis,”Proc. Natl. Acad. Sci. USA, Jun. 1988, 85, 3928-3932.
Goodwin, C.B., et al., “A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions,”Spine, 1999, 24(13), 1349-1356.
Grodzinsky, A.J., “Electromechanical and physicochemical properties of connective tissue,”Crit. Rev. Biomed. Engng., 1983, 9(2), 133-198.
Harrison, M.H.M., et al., “Use of pulsed electromagnetic fields in perthes disease: report of a pilot study,”J. Pediatr. Orthop., 1984, 4, 579-584.
Jiang, X., et al., “siRNA mediated inhibition of MMP-

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