Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2005-07-19
2005-07-19
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S377000, C435S173800, C607S065000
Reexamination Certificate
active
06919205
ABSTRACT:
Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate specific and selective fields optimized for type II collagen gene expression and exposing cartilage tissue to the specific and selective fields generated by specific and selective signals so as to regulate type II collagen gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.
REFERENCES:
patent: 4509520 (1985-04-01), Dugot
patent: 4535775 (1985-08-01), Brighton et al.
patent: 4600010 (1986-07-01), Dugot
patent: 4683873 (1987-08-01), Cadossi et al.
patent: 5014699 (1991-05-01), Pollack et al.
patent: 5038797 (1991-08-01), Batters
patent: 5269746 (1993-12-01), Jacobson
patent: 5273033 (1993-12-01), Hoffman
patent: 5338286 (1994-08-01), Abbott et al.
patent: 5374283 (1994-12-01), Flick
patent: 5743844 (1998-04-01), Tepper et al.
patent: 5968527 (1999-10-01), Litovitz
patent: 6083149 (2000-07-01), Wascher et al.
patent: 6132362 (2000-10-01), Tepper et al.
patent: 6186940 (2001-02-01), Kirschbaum
patent: 6261221 (2001-07-01), Tepper et al.
patent: 6485963 (2002-11-01), Wolf et al.
patent: WO 00/02585 (2000-01-01), None
patent: WO 01/62336 (2001-08-01), None
Aaron, R.K., et al., “The conservative treatment of osteonecrosis of the femoral head,”Clin. Orthop., 1989, 249, 209-218.
Aaron, R.K., et al., “Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields,”J. Bone Miner. Res., Nov. 2, 1989, 4, 227-233.
Bassett,C.A.L., “Low energy pulsing electromagnetic fields modify biomedical processes,”BioEssays, 1987, 6(1) , 36-42.
Bassett, C.A.L., et al., “Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis,”Clin. Orthop., Sep. 1989, 246, 172-185.
Bassett, C.A.L., et al., “Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMSs),”Crit. Rev. Biomed. Eng., 1989, 17(5), 451-529.
Bassett, C.A.L., et al., “Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses,”JAMA, Feb. 5, 1982, 247(5), 623-628.
Binder, A., et al., “Pulsed electromagnetic field therapy of persistent rotator cuff tendonitis,”Lancet, Mar. 31, 1984, 695-698.
Brighton, C.T., et al., “A multicenter study of the treatment of non-union with constant direct current,”J. Bone and Joint Surgery, Jan. 1981, 62-A(1), 2-13.
Brighton, C.T., et al., “Treatment of recalcitrant non-union with a capacitively coupled electrical field,”J. Bone and Joint Surgery, Apr. 1985, 67-A(4), 577-585.
Brighton, C.T., et al., “Treatment of castration-induced osteoporosis by a capacitively coupled electrical signal in rat vertebrae,”J. Bone and Joint Surgery, Feb. 1989, 71-A(2), 228-236.
Brighton, C.T., et al., “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes,”J. Orthop. Res., 1988, 6, 552-558.
Brighton, C.T., et al., “Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resorption,”J. Orthop. Res., 1988, 6, 676-684.
Goodman, R., et al., “Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis,”Proc. Natl. Acad. Sci. USA, Jun. 1988, 85, 3928-3932.
Goodwin, C.B., et al., “A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions,”Spine, 1999, 24(13), 1349-1356.
Grodzinsky, A.J., “Electromechanical and physicochemical properties of connective tissue”Crit. Rev. Biomed. Engng., 1983, 9(2), 133-198.
Harrison, M.H.M., et al., “Use of pulsed electromagnetic fields in perthes disease: report of a pilot study,”J. Pediatr. Orthop., 1984, 4, 579-584.
Jones, D.B., et al., “PEMF effects of differentiation and division in mirine melanoma cells are mediated indirectly through cAMP,”Trans. BRAGS 6, 1986, 51.
Lorich, D.G., et al., “Biochemical pathway mediating the response of bone cells to capacitive coupling,”Clin. Orthop. and Related Res., 1998, 350, 246-256.
Massardo, L., et al., “Osteoarthritis of the knee joint: an eight year prospective study,”Ann Rheum Dis., 1989, 48, 893-897.
Mooney, V., “A randomized double-blind prospective study of the efficacy of pulsed electromagnetic fields for inter body lumbar fusions,”Spine, 1990, 15(7), 708-712.
Norton, L.A., et al., “Pulsed electromagnetic fields alter phenotypic expression in chondroblasts in tissue culture,”J. Orthop. Res., 1988, 6, 685-689.
Rodan, G.A., et al., “DNA synthesis in cartilage cells is stimulated by oscillating electric fields,”Science, Feb. 10, 1978, 199, 690-692.
Ryaby, J.T., et al., “Pulsing electromagnetic fields affect the phosphorylation and expression of oncogene proteins,”Trans. BRAGS 6, 1986, p. 78.
Ryaby, J.T., et al., “The effect of electromagnetic fields on protein phosphorylation and synthesis in murine melanoma cells,”Trans, BRAGS 6, 1986, p. 32.
Wang, W. et al., “The increased level of PDGF-A contributes to increased proliferation induced by mechanical stimulation in osteoblastic cells,”Biochem. Biophys. Res. Commun., Oct. 1997, 43(2), 339-346.
Wang, W., et al., “The increased level of PDGF-A contributes to the increased proliferation induced by mechanical stimulation in osteoblastic cells,”Biochem. Biophys. Res. Commun., Oct. 1997, 43(2), 339-346.
Zhuang, H., et al., “Electrical stimulation induces the level of TGF-β1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway,”Biochem. Biophys. Res. Commum., 1997, 237, 225-229.
Brighton, C.T., et al., “Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields,”J. Orthop. Res., 1985, 3, 331-340.
Brighton, C.T., et al.,“In vitro bone-cell response to a capacitively coupled electrical field,”Clin. Orthop. Related Res., Dec. 1992, 285, 255-262.
Carter, E.L., et al., “Field distributions in vertebral bodies of the rat during electrical stimulation: a parametric study,”IEEE Trans. on Biomed. Eng., Mar. 1989, 36(3), 333-345.
Copy of the PCT International Search Report dated Aug. 5, 2004 (PCT/US03/31793).
Ketter James
The Trustees of the University of Pennsylvania
LandOfFree
Regulation of type II collagen gene expression using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Regulation of type II collagen gene expression using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regulation of type II collagen gene expression using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3412074