Regulation of transcription factor, NF-IL6/LAP

Details Regulation of transcription factor, NF-IL6/LAP Regulation of transcription factor, NF-IL6/LAP

2008-01-15

2008-01-15

Harris, Alana M. (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C435S004000, C435S007200, C435S194000, C436S086000

Reexamination Certificate

active

07319134

ABSTRACT:
An alteration in phosphorylation of serine 105, within the activation domain of NF-IL6/LAP, alters its transcriptional efficacy. Polypeptides, polynucleotides and methods of use for modified transcriptional activators allow regulation of gene expression.

REFERENCES:
patent: WO 91/08774 (1991-06-01), None
Lazar et al. Molecular and Cellular Biology 8(3): 1247-1252, Mar. 1988.
GenCore Database sheet, Sequence alignment between Applicants' sequence ID No. 1 and Chang and Akira sequences, 1 sheet.
GenCore database alignment between Applicants' SEQ ID No. 1 and SEQ ID No. 4 with Chang et al. (Dec. 1990) and Akira et al (1990).
Amino acid database, GenCore. Sequence alignment between instant application's SEQ ID No. 1 and Descombes et al. Genes Dev. 4: 1541-1551, 1990/ IDS reference, AE submitted Sep. 16, 2002.
Amino acid database, GenCore. Sequence alignment between instant application's SEQ ID No. 4 and Chang et al. Molecular and Cellular Biology 10(12): 6642-6653, Dec. 1990/ Reference AC from IDS submitted Sep. 16, 2002.
Amino acid database, GenCore. Sequence alignment between instant application's SEQ ID No. 1 and Poli et al. Cell 63: 643-653, Nov. 2, 1990/ IDS reference, AG Submitted Sep. 16, 2002.
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Descombes and Schibler, “A Liver-Enriched Transcriptional Activator Protein, LAP, and a Transcriptional Inhibitory Protein, LIP, are Translated from the Same mRNA,”Cell, 67:569-579, Cell Press (1991).
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Poli et al., “IL-6DBP, a Nuclear Protein Involved in Interleukin-6 Signal Transduction, Defines a New Family of Leucine Zipper Proteins Related to C/EBP,”Cell, 63:643-653, Cell Press (1990).
Ron and Habener, “CHOP, a Novel Developmentally Regulated Nuclear Protein that Dimerizes with Transcription Factors C/EBP and LAP and Functions as a Dominant-Negative Inhibitor of Gene Transcription,”Genes&Development, 6:439-453, Cold Spring Harbor Laboratory Press (1992).
Trautwein et al., “Transactivation by NF-IL6/LAP is Enhanced by Phosphorylation of its Activation Domain,”Nature, 364:544-547 (1993).

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