Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1994-12-06
1997-09-09
Adams, Donald E.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
514824, C12N 506, C12N 508
Patent
active
056655916
ABSTRACT:
This invention relates to agents that regulate the proliferation of cells such as smooth muscle cells. Proliferation of smooth muscle cells may be increased or decreased by affecting the activity or concentration of a transcription factor. The factor comprises two domains of about 50 kD and about 70 kD which together have an approximate molecular weight of 120 kD and specifically binds to the nucleic acid sequence 5'-GGGTTTTCCCC-3' (SEQ ID NO 2). This factor represents a novel member of the family of rel-related factors. This invention also relates to methods for the treatment and prevention of diseases and disorders associated with proliferation of smooth muscle cells such as arteriosclerosis, fibrosis and wound healing, which involve regulation of the smooth muscle cell transcription factor. The invention further relates to purified transcription factor, to pharmaceutical compositions containing transcription factor or inhibitors or inducers of the transcription factor, to nucleic acid sequences which code for the subunits of the factor, and to recombinant cells transformed with these sequences. Novel rel-related factors can also be used to regulate gene expression and the proliferation of organisms such as cells and viruses which may contain rel-related binding elements.
REFERENCES:
patent: 4444778 (1984-04-01), Coughlin
patent: 4534967 (1985-08-01), Jacobson et al.
patent: 4824436 (1989-04-01), Wolinsky
patent: 4945086 (1990-07-01), Benitz et al.
patent: 5019562 (1991-05-01), Folkman et al.
patent: 5032679 (1991-07-01), Brandley et al.
patent: 5053033 (1991-10-01), Clarke
patent: 5102402 (1992-04-01), Dror et al.
patent: 5112827 (1992-05-01), Saunders et al.
patent: 5116864 (1992-05-01), March et al.
patent: 5125888 (1992-06-01), Howard et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5208019 (1993-05-01), Hansson et al.
patent: 5229493 (1993-07-01), Folkman et al.
patent: 5241049 (1993-08-01), Goodman et al.
patent: 5242397 (1993-09-01), Barath et al.
patent: 5242692 (1993-09-01), Djaldetti et al.
patent: 5250519 (1993-10-01), Conrad et al.
patent: 5254342 (1993-10-01), Shen et al.
patent: 5268358 (1993-12-01), Fretto
patent: 5270047 (1993-12-01), Kauffman et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5280016 (1994-01-01), Conrad et al.
patent: 5283257 (1994-02-01), Gregory et al.
patent: 5284868 (1994-02-01), Dell et al.
patent: 5288711 (1994-02-01), Mitchell et al.
patent: 5298018 (1994-03-01), Narciso, Jr.
patent: 5302168 (1994-04-01), Hess
patent: 5304121 (1994-04-01), Sahatjian
patent: 5304473 (1994-04-01), Belagaje et al.
patent: 5304541 (1994-04-01), Purchio et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5314688 (1994-05-01), Kauffman et al.
patent: 5322678 (1994-06-01), Morgan, Jr. et al.
patent: 5324655 (1994-06-01), Kriegler et al.
patent: 5326559 (1994-07-01), Miller
patent: 5328695 (1994-07-01), Lucas et al.
"Probucol Decreases Neointimal Formation in a Swine Model of Coronary Artery Ballon Injury", Joel E. Schneider, MD et al., Circulation, vol. 88, No. 2, Aug. 1993, pp. 628-637.
"Probucol inhibits neointimal thickening and macrophage accumulation after ballon injury in the cholesterol-fed rabbit", Gordon A. A. Fems et al., Proc. Natl. Acad. Sci. USA, vol. 89, pp. 11312-11316, Dec. 1992.
"Probucol alternates the development of aortic atherosclerosis in cholesterol-fed rabbits", Br. J. Pharmacol., Alan Daugherty et al., Br. J. Pharamacol, (1989), vol. 98, pp. 612-618.
"NF-kB and Rel: Participants in a Multiform Transcriptional Regulatory System", Mariagrazia Grilli et al., International Review of Cytology, vol. 143, pp. 2-62.
"The inducible transcription factor NF-kB: structure-function relationship of its protein subunits", S. Grimm et al., Bio Chem J., pp. 297-308.
"The Antioxidant Butylated Hydroxytoluene Protects Against Atherosclerosis", Ingemar Bjorkhem et al., Arteriosclerosis and Thrombosis, vol. 1, No. 11, Jan./Feb. 1991.
"Antioxidant Treatment Inhibits the Development of Intimal Thickening after Balloon Injury of the Aorta in Hypercholesterolemic Rabbits", Annaa Freyschuss et al., J. Clin. Invest, vol. 91, Apr. 1993, pp. 1282-1288.
"Vascular Smooth Muscle Cells Express a Constitutive NF-kB-like Activity", Roger Lawrence et al., The Journal of Biological Chemistry, vol. 269, No. 46, Issue of Nov. 18, pp. 28913-28918, 1994.
"Collagen Synthesis by Human Intestinal Smooth Muscle Cells in Culture", Martin F. Graham et al., Gastroenterology 1987, vol. 92, pp. 400-405.
"The p50 subunit of NF-kB associates with the NF-IL6 transcription factor", Kenneth P. LeClair et al., Proc. Natl. Acad. Sci. USA, vol. 89, pp. 8145-8149, Sep. 1992.
"In Vitro Effects of Pentoxifylline on Smooth Muscle Cell Migration and Blood Monocyte Production of Chemotactic Activity for Smooth Muscle Cell: Potential Therapeutic Benefit in the Adult Respiratory Distress Syndrome", Anne Kullmann et al., American Journal of Respiratory Cell and Molecular Biology vol. 8, 1993, pp. 83-88.
"Stricture Formation Pathophysiologic and Therapeutic Concepts", Martin F. Graham, pp. 323-335.
"Biology of Uterine Myomas amd Myometrium In Vitro", Mitchell S. Rein M.D. et al., Seminars in Reproductive Endocrinology, vol. 10, No. 4, Nov. 1992, pp. 310-319.
"The Alimentary Canal", Martin F. Graham, M.D. et al., Repair of Specific Tissues, pp. 433-449.
"NF-kB p100 Is One of the High-Molecular-Weight Proteins Complexed with the v-Rel Oncoprotein in Transformed Chicken Spleen Cells", Journal of Virology, Dec. 1993, pp. 7612-7617.
Rojanasasul, Adv. Drug Del. Rev., vol. 18, pp. 115-131, 1996.
Porreca et al., Artherosclerosis, vol. 99, pp. 71-78, Feb. 1993.
Bellas Robert E.
Lawrence Roger
Sonenshein Gail E.
Adams Donald E.
Gucker Stephen
Remenick James
Trustees of Boston University
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