Regulation of matrix metalloproteinase gene expression using...

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Metabolism of micro-organism enhanced

Reexamination Certificate

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C607S050000

Reexamination Certificate

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07429471

ABSTRACT:
Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for reduction of matrix metalloproteinase gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate matrix metalloproteinase gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, cartilage defects, and tumor metastasis.

REFERENCES:
patent: 4430999 (1984-02-01), Brighton et al.
patent: 4442846 (1984-04-01), Brighton et al.
patent: 4467808 (1984-08-01), Brighton et al.
patent: 4467809 (1984-08-01), Brighton
patent: 4487834 (1984-12-01), Brighton
patent: 4506674 (1985-03-01), Brighton et al.
patent: 4509520 (1985-04-01), Dugot
patent: 4535775 (1985-08-01), Brighton et al.
patent: 4549547 (1985-10-01), Brighton et al.
patent: 4600010 (1986-07-01), Dugot
patent: 4683873 (1987-08-01), Cadossi et al.
patent: 4998532 (1991-03-01), Griffith
patent: 5014699 (1991-05-01), Pollack et al.
patent: 5038797 (1991-08-01), Batters
patent: 5269746 (1993-12-01), Jacobson
patent: 5273033 (1993-12-01), Hoffman
patent: 5338286 (1994-08-01), Abbott et al.
patent: 5374283 (1994-12-01), Flick
patent: 5743844 (1998-04-01), Tepper et al.
patent: 5968527 (1999-10-01), Litovitz
patent: 6083149 (2000-07-01), Wascher et al.
patent: 6132362 (2000-10-01), Tepper et al.
patent: 6186940 (2001-02-01), Kirschbaum
patent: 6261221 (2001-07-01), Tepper et al.
patent: 6292699 (2001-09-01), Simon et al.
patent: 6485963 (2002-11-01), Wolf et al.
patent: 6605089 (2003-08-01), Michelson
patent: 6747004 (2004-06-01), Tabibzadeh
patent: 6919205 (2005-07-01), Brighton
patent: 6955642 (2005-10-01), Simon
patent: 7022506 (2006-04-01), Brighton et al.
patent: 7130692 (2006-10-01), Brighton et al.
patent: 7158835 (2007-01-01), Brighton et al.
patent: 7167753 (2007-01-01), Brighton et al.
patent: 7215995 (2007-05-01), Brighton et al.
patent: 2002/0052634 (2002-05-01), March
patent: 2002/0125769 (2002-09-01), Riley et al.
patent: 2003/0211084 (2003-11-01), Brighton et al.
patent: 2004/0138709 (2004-07-01), Brighton
patent: 2005/0203591 (2005-09-01), Brighton
patent: 2006/0190043 (2006-08-01), Brighton et al.
patent: 2006/0235473 (2006-10-01), Brighton
patent: 2007/0299472 (2007-12-01), Brighton
patent: 1198580 (2006-05-01), None
patent: WO 00/02585 (2000-01-01), None
patent: 01162336 (2001-08-01), None
patent: WO 01/62336 (2001-08-01), None
patent: 2005070136 (2005-08-01), None
patent: WO 2005/070136 (2005-08-01), None
Jiang et al., Journal of Cellular Physiology, vol. 202, 2005, pp. 723-730.
Ala-aho et al., Oncogene, vol. 23, 2004, pp. 5111-5123.
Aaron, R.K., et al., “The conservative treatment of osteonecrosis of the femoral head,”Clin. Orthop., 1989, 249, 209-218.
Aaron, R.K., et al., “Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields,”J. Bone Miner. Res., Nov. 2, 1989, 4, 227-233.
Bassett,C.A.L., “Low energy pulsing electromagnetic fields modify biomedical processes,”BioEssays, 1987, 6(1) , 36-42.
Bassett, C.A.L., et al., “Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis,”Clin. Orthop., Sep. 1989, 246, 172-185.
Bassett, C.A.L., et al., “Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMSs),”Crit. Rev. Biomed. Eng., 1989, 17(5), 451-529.
Bassett, C.A.L., et al., “Pulsing electromagnetic field treatment in ununited fractures and failed arthrodeses,”JAMA, Feb. 5, 1982, 247(5), 623-628.
Binder, A., et al., “Pulsed electromagnetic field therapy of persistent rotator cuff tendonitis,”Lancet, Mar. 31, 1984, 695-698.
Brighton, C.T., et al., “A multicenter study of the treatment of non-union with constant direct current,”J. Bone and Joint Surgery, Jan. 1981, 63-A(1), 2-12.
Brighton, C.T., et al., “Treatment of recalcitrant non-union with a capacitively coupled electrical field,”J. Bone and Joint Surgery, Apr. 1985, 67-A(4), 577-585.
Brighton, C.T., et al., “Treatment of castration-induced osteoporosis by a capacitively coupled electrical signal in rat vertebrae,”J. Bone and Joint Surgery, Feb. 1989, 71-A(2), 228-236.
Brighton, C.T., “Increased cAMP production after short-term capacitively coupled stimulation in bovine growth plate chondrocytes,”J. Orthop. Res., 1988, 6, 552-558.
Brighton, C.T., et al., “Treatment of denervation/disuse osteoporosis in the rat with a capacitively coupled electrical signal: effects on bone formation and bone resporption,”J. Orthop. Res., 1988, 6, 676-684.
Goodman, R., et al., “Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis,”Proc. Natl. Acad. Sci. USA, Jun. 1988, 85, 3928-3932.
Goodwin, C.B., et al., “A double-blind study of capacitively coupled electrical stimulation as an adjunct to lumbar spinal fusions,”Spine, 1999, 24(13), 1349-1356.
Grodzinsky, A.J., “Electromechanical and physicochemical properties of connective tissue,”Crit. Rev. Biomed. Engng., 1983, 9(2), 133-199.
Harrison, M.H.M., et al., “Use of pulsed electromagnetic fields in perthes disease: report of a pilot study,”J. Pediatr. Orthop., 1984, 4, 579-584.
Jones, D.B., et al., “PEMF effects on differentiation and division in mirine melanoma cells are mediated indirectly through cAMP,”Trans. BRAGS 6, 1986, 51.
Lorich, D.G., et al., “Biochemical pathway mediating the response of bone cells to capacitive coupling,”Clin. Orthop. and Related Res., 1998, 350, 246-256.
Massardo, L., et al., “Osteoarthritis of the knee joint: an eight year prospective study,”Ann Rheum Dis., 1989, 48, 893-897.
Mooney, V., “A randomized double-blind prospective study of the efficacy of pulsed electromagnetic fields for inter body lumbar fusions,”Spine, 1990, 15(7), 708-712.
Brighton, C.T., et al., “Fracture healing in the rabbit fibula when subjected to various capacitively coupled electrical fields,”J. Orthop. Res., 1985, 3, 331-340.
Brighton, C.T., et al., “In vitro bone-cell response to a capacitively coupled electrical field,”Clin. Orthop. Related Res., Dec. 1992, 285, 255-262.
Carter, E.L., et al., “Fields distributions in vertebral bodies of the rat during electrical stimulation: a parametric study,”IEEE Trans. on Biomed. Eng., Mar 1989, 36(3), 333-345.
Brighton, C.T., et al., “Signal transduction in electrically stimulated bone cells,”J. Bone Joint Surg. Am., 2001, 83-A(10), 1514-1523.
Pienkowski, D., et al., “Low-power electromagnetic stimulation of osteotomized rabbit fibuiae,”J. of Bone&Joint Surgery, 1994, 76-A(4), 489-501.
Wang, W., et al., “Up-regulation of chondrocyte matrix genes and products by electric fields,”Clin. Orthopaedics&Related Res., 2004, 427S, S163-S173.
Norton, L.A., et al., “Pulsed electromagnetic fields alter phenotypic expression in chondroblasts in tissue culture,”J. Orthop. Res., 1988, 6, 685-689.
Rodan, G.A., et al., “DNA synthesis in cartilage cells is stimulated by oscillating electric fields,”Science, Feb. 10, 1978, 199, 690-692.
Ryaby, J.T., et al., “Pulsing electromagnetic fields affect th

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