Regulation of hypoxia-inducible gene expression with...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C514S04400A, C536S024310, C536S024330

Reexamination Certificate

active

10496945

ABSTRACT:
A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase angiogenesis, to stimulate HIF-1α function, to treat hypoxia-related conditions, and to maintain normal cell functions under hypoxia.

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Agrawal 2000, Antisense therapeutics: is it as simple as complementary base recognition? Mol. Med. Today, vol. 61, 72-81.
Jen et al. Suppresion of Gene Expression by Targeted Disruption of Messenger RNA: Available Options and Current Strategies. Stem Cells (2000), vol. 18:307-319. AlphaMed Press.
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Gradin et al, Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor, Molecular and Cell Biology, vol. 16, No. 10, Oct. 1996, pp. 5221-5231.
Accession No. AI322407; Oct. 20, 1998.

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