Regulation of human serine/threonine kinase

Details Regulation of human serine/threonine kinase Regulation of human serine/threonine kinase

2007-02-20

2007-02-20

Swope, Sheridan (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

Reexamination Certificate

active

10514201

ABSTRACT:
Reagents that regulate human serine/threonine kinase and reagents which bind to human serine/threonine kinase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, diabetes, neurological disorders, cardiovascular disorders, musculo-skeletal disorders, inflammatory disorders, genitourological disorders, and respiratory disorders (e.g., asthma and COPD).

REFERENCES:
patent: WO 02 18557 (2002-03-01), None
patent: WO 02 46384 (2002-06-01), None
Cohen et al, Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts. Methods Enzymol. 1991;201:389-98. Review.
Tonks et al, Purification and assay of CD45: an integral membrane protein-tyrosine phosphatase. Methods Enzymol. 1991;201:442-51.
Database Embl ‘On line! EBI; SEQ ID No.: 2 from WO0218557 Mar. 7, 2002 Bandman et al.: “Human PKIN-2 protein” Database accession No. AAE21707 XP002248930.
Leung Thomas et al.: “Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.” Molecular and Cellular Biology, vol. 18, No. 1, Jan. 1998, pp. 130-140, XP002248927 ISSN: 0270-7306, p. 131, paragraph 1; figures 2,3.
Database Swall ‘On line? EBI; Jun. 1, 1998, Leung T: “Mytonic dystrophy kinase-related Cdc42-binding kinase” Database accession No. 054874 XP002248931.
Dong Jing-Ming et al: “Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK)on myosin light chain phosphorylation.” European Journal of Cell Biology, vol. 81, No. 4, Apr. 2002 pp. 231-242, XP002248928 ISSN: 0171-9335.
Tan Ivan et al: “Intermolecular and Intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha.” Molecular and Cellular Biology, vol. 21, No. 8, Apr. 2001, pp. 2767-2778, XP002248929 ISSN: 0270-7306.
Database Embl ‘On line!EBI;SEQ ID NO: 19 from WO02/46384, Jun. 3, 2002, Yue et al (Incyte Genomics): Human kinase and phosphatase-19 (KAP-19) protein” Database accession No. AAE25099, XP002248932.
Tan I et al: “Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity” Gene: An International Journal of Genes and Genomes, Elsevier Science Publishers, Barking, GB, vol. 304, Jan. 30, 2003, pp. 107-115, XP004406357 ISSN: 0378-1119.

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