Regulation of human prostasin-like serine protease

Details Regulation of human prostasin-like serine protease Regulation of human prostasin-like serine protease

2006-05-23

2006-05-23

Siew, Jeffrey (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100

Reexamination Certificate

active

07049420

ABSTRACT:
Reagents which regulate human prostasin-like enzyme activity and reagents which bind to human prostasin-like enzyme gene products can be used to regulate human prostasin-like enzyme activity. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation, atherosclerosis, neurodegenerative diseases, and pathogenic infections.

REFERENCES:
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patent: WO 01/24815 (2001-04-01), None
patent: WO 01/75067 (2001-10-01), None
patent: WO 01/98467 (2001-12-01), None
patent: WO 01/98468 (2001-12-01), None
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Marshal (Science 1995; 269 (5227): 1050-1055).
Eck et al. (Goodman & Gilman's The Pharmacological Basis of Therapeutics (1996), 9th Edition, Chapter 5, McGraw-Hill, NY).
Juengst (British Medical Journal 2003; 326: 1410-1411.
Rubanyi (Mol. Aspects Med. 2001; 22: 113-142.
Database JBC Online “Online!” htpp://www.jbc.org. (XP002935257) cited in Yu J X et al Molecular Cloning, Tissue-Specific Expression, and Cellular Localization of Human Prostasin MRNA, Journal of Biological Chemistry, vol. 270 (22), 1995, 13483-13489.

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