Regulation of human PLC delta-1

Details Regulation of human PLC delta-1 Regulation of human PLC delta-1

2006-05-23

2006-05-23

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S193000, C514S012200

Reexamination Certificate

active

07049089

ABSTRACT:
Reagents which regulate human PLC delta-1 activity and reagents which bind to human PLC delta-1 gene products can be used, inter alia, to treat COPD, congestive heart failure, hypertension, and cancer, and a variety of conditions in which signal transduction is impaired.

REFERENCES:
patent: WO 01/53468 (2001-07-01), None
patent: WO 01/55300 (2001-08-01), None
patent: WO 01/66764 (2001-09-01), None
Database EM—(Online) EMBL: Accession No: A1369426, Jan. 13, 1999. “Homo sapiens cDNA clone IMAGE:2019525 3 similar Phospholipase C-Delta 1.”, XP002197071.
Cheng Hwei-Fang et al., “Cloning and identification of amino acid residues of human phospholipase C-delta-1 essential for catalysis”, Journal of Biological Chemistry, Mar. 10, 1995, vol. 270, No. 10, pp. 5495-5505, XP002197068.
Wang Tieli et al. “The pleckstrin homology domain of phospholipase C-beta2 links the binding of Gbetagamma to activation of the catalytic core”, Journal of Biological Chemistry, Mar. 17, 2000, vol. 275, No. 11, pp 7466-7469, XP002197069.
Ghosh Smita et al., “Phospholipase C isoforms delta-1 and delta-3 from human fibroblasts”, Protein Expression and Purification, Mar. 1997, vol. 9, No. 2, pp. 262-278, XP001073550.
Database EMBL (Online), Accession No: AAU18956, Nov. 21, 2001, Human Genome Science, “Novel Lung Cancer Antigen”, XP002197416.

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