Regulation of human caspase-1-like protease

Details Regulation of human caspase-1-like protease Regulation of human caspase-1-like protease

2007-03-20

2007-03-20

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C435S219000, C435S069100, C435S320100, C435S226000, C536S023100

Reexamination Certificate

active

11357125

ABSTRACT:
Screening methods to identify candidate therapeutic agents using a newly identified human caspases-1-like protease.

REFERENCES:
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patent: 5858778 (1999-01-01), Alnemri et al.
patent: 5869315 (1999-02-01), Talanian et al.
Alnemri et al., “Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities”,J. Biol ChemMar. 3, 1995; 270(9):4312-4317.
Stosic-Grujicic et al., “Modulatory in vitro effects of interleukin-1 receptor antagonist (IL-1Ra) or antisense oligonucleotide to interleukin-1 beta converting enzyme (ICE) on acute myeloid leukaemia (AML) cell growth”,Clin Lab Haematol. Jun. 1999;21 (3):173-85.
Estrov et al., “Role of interleukin-1 beta converting enzyme (ICE) in leukemia”,Cytokines Mol Ther. Mar. 1996; 2(1):1-11.
Zhu et al., “Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease”,J Neuropathol Exp Neurol. Jun. 1999; 58(6):582-7.
Masliah et al., “Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer diease”,J Neuropathol Exp Neurol. Nov. 1998; 57(11):1041-52.
Suzuki, “Amyloid beta-protein induces necrotic cell death mediated by ICE cascade in PC12 cells”,Exp Cell Res. Aug. 1, 1997; 234(2):507-11.
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Wilson et al., “Structure and mechanism of interleukin-1β converting enzyme”, Nature, 370, 1999, pp. 270-275.
Romanowski et al., “Crystal structures of a ligand-free and malonate-bound human caspase-1: Implications for the mechanism of substrate binding”, Structure, vol. 12, 2004, pp. 1361-1371.
Concha et al., “Controlling apoptosis by inhibition of caspase”, Current Medicinal Chemistry, 2002, 9, pp. 713-726.
Database Swall [Online] Apr. 1, 1993 Thornberry, N.A.., et al.: “Interleukin-1 Beta Convertase (IL-1BC) (EC 3.4.22.36)” retrieved from EBI Database accession No. P29466 (XP002192392.
Database EMBL [Online] Oct. 10, 1998 Robert Strausberg: “similar to gb:M87507 Interleukin-1 Beta Convertase Precursor (Human)” retrieved from EBI Database accession No. A1189378 (XP002192390.
Database EMBL [Online] Oct. 28, 1998 Robert Strausberg: “similar to gb:M87507 Interleukin-1 Beta Convertase” retrieved from RBI Database accession No. AI220630 (XP002192391.
Cohen et al., J. Biochem, 1997, 326, pp. 1-16.

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